Tchem MYOC Myocilin

Protein Classes

PANTHER Classes

Protein / Structural Protein / Myocilin

Protein / Receptor / Myocilin

DTO Classes

Protein / Cellular Structure / Myocilin

Protein Summary

Description

Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork. MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99972
• B2RD84
• O00620
• Q7Z6Q9

Gene Name

• MYOC

Ensembl ID

• ENST00000037502
• ENSP00000037502
• ENSG00000034971

Symbol

• GLC1A
• TIGR
• GPOA
• JOAG
• TIGR
• GLC1A
• JOAG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.96
biological term	0.92
biological process	0.91
gene perturbation	0.84
cell type or tissue	0.63

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.61   (req: < 5)

Gene RIFs: 186   (req: <= 3)

Antibodies: 226   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.61   (req: >= 5)

Gene RIFs: 186   (req: > 3)

Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

CHEMBL339587

MYOCTchem

Kd : 7

CHEMBL1432046

MYOCTchem

Kd : 6.19

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1	1	1		64.9
daytime rest measurement	EFO_0007828	1	1	1		64.4
glomerular filtration rate	EFO_0005208	1	1	0	6.8	50.6
red blood cell distribution width	EFO_0005192	1	1	1		49.5
mathematical ability	EFO_0004875	1	1	1		42.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1		64.9
daytime rest measurement	EFO_0007828	1		64.4
glomerular filtration rate	EFO_0005208	0	6.8	50.6
red blood cell distribution width	EFO_0005192	1		49.5
mathematical ability	EFO_0004875	1		42.3

Reset Zoom  Beta Count   Odds Ratio

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myocilin	VGNC:8395	457511
Macaque	myocilin		704406
Mouse	myocilin	MGI:1202864	17926
Rat	myocilin	RGD:620430	81523
Dog	myocilin	VGNC:43576	490344

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myocilin
Macaque	myocilin
Mouse	myocilin
Rat	myocilin
Dog	myocilin

Protein Structure (3 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99972-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Gene Ontology Terms (36)

Functions (5)

Components (12)

Processes (19)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
fibronectin binding	Inferred from Physical Interaction (IPI)	UniProtKB
frizzled binding	Inferred from Physical Interaction (IPI)	UniProtKB
myosin light chain binding	Inferred from Physical Interaction (IPI)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
receptor tyrosine kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (75)

Explore Interacting Targets

1 – 10 of 75

• See Interactions on String-DB

WDR36

Tbio

Novelty:  0.02010676

Score:  0.939

Data Source:  STRINGDB

OPTN

Tbio

Novelty:  0.00080427

Score:  0.879

Data Source:  STRINGDB

CYP1B1

Tchem

Novelty:  0.00090917

Score:  0.857

Data Source:  STRINGDB

ASB10

Tbio

Novelty:  0.08667666

Score:  0.754

Data Source:  STRINGDB

TMCO1

Tbio

Novelty:  0.04473381

Score:  0.688

Data Source:  STRINGDB

LTBP2

Tbio

Novelty:  0.013159

Score:  0.684

Data Source:  STRINGDB

FN1

Tchem

Novelty:  0.00003647

Score:  0.675

Data Source:  STRINGDB

TMTC1

Tbio

Novelty:  0.0063204

Score:  0.66

Data Source:  STRINGDB

PEX5

Tbio

Novelty:  0.00560901

Score:  0.641

Data Source:  STRINGDB

CRYBB1

Tbio

Novelty:  0.01083645

Score:  0.627

Data Source:  STRINGDB

Publication Statistics

PubMed Score  782.61

PubMed score by year

Reset Zoom

PubTator Score  490.61

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Calcium
Cell projection
Cilium
Coiled coil
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Disease mutation
Disulfide bond

GWAS Trait Find Similar Targets

No Header	No Header
daytime rest measurement
glomerular filtration rate
mathematical ability
mean platelet volume
red blood cell distribution width
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
vision/eye phenotype