Protein Summary
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-assoc ...more
- ENST00000037502
- ENSP00000037502
- ENSG00000034971
- GLC1A
- TIGR
- GPOA
- JOAG
- TIGR
- GLC1A
- JOAG1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.96 | ||
biological term | 0.92 | ||
biological process | 0.91 | ||
gene perturbation | 0.84 | ||
cell type or tissue | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 782.61 (req: < 5)
Gene RIFs: 186 (req: <= 3)
Antibodies: 226 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 782.61 (req: >= 5)
Gene RIFs: 186 (req: > 3)
Antibodies: 226 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (75)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (36)
Functions (5)
Components (12)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 64.9 | |||||
daytime rest measurement | 1 | 1 | 1 | 64.4 | |||||
glomerular filtration rate | 1 | 1 | 0 | 6.8 | 50.6 | ||||
red blood cell distribution width | 1 | 1 | 1 | 49.5 | |||||
mathematical ability | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 64.9 | |||||
daytime rest measurement | 1 | 64.4 | |||||
glomerular filtration rate | 0 | 6.8 | 50.6 | ||||
red blood cell distribution width | 1 | 49.5 | |||||
mathematical ability | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myocilin | VGNC:8395 | 457511 | |||||
Macaque | myocilin | 704406 | ||||||
Mouse | MGI:1202864 | 17926 | ||||||
Rat | RGD:620430 | 81523 | ||||||
Dog | myocilin | VGNC:43576 | 490344 | |||||
Publication Statistics
PubMed Score 782.61
PubMed score by year
PubTator Score 490.61
PubTator score by year
Related Publications
Text Mined References (245)
GeneRif Annotations (186)
Items per page:
0 of 0
PMID | Year | Title |
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