You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MYOC
Myocilin

Protein Summary
Description
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-assoc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000037502
  • ENSP00000037502
  • ENSG00000034971

Symbol
  • GLC1A
  • TIGR
  • GPOA
  • JOAG
  • TIGR
  • GLC1A
  • JOAG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.96
biological term
0.92
biological process
0.91
gene perturbation
0.84
cell type or tissue
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.61   (req: < 5)
Gene RIFs: 186   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.61   (req: >= 5)
Gene RIFs: 186   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
64.9
daytime rest measurement
1
1
1
64.4
glomerular filtration rate
1
1
0
6.8
50.6
red blood cell distribution width
1
1
1
49.5
mathematical ability
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
64.9
daytime rest measurement
1
64.4
glomerular filtration rate
0
6.8
50.6
red blood cell distribution width
1
49.5
mathematical ability
1
42.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myocilin
VGNC:8395
457511
Macaque
myocilin
704406
Mouse
MGI:1202864
17926
Rat
RGD:620430
81523
Dog
myocilin
VGNC:43576
490344
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myocilin
Macaque
myocilin
Mouse
Rat
Dog
myocilin
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99972-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (36)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (75)
1 – 10 of 75
WDR36
Tbio
Novelty:  0.02010676
Score:  0.939
Data Source:  STRINGDB
OPTN
Tbio
Novelty:  0.00080427
Score:  0.879
Data Source:  STRINGDB
CYP1B1
Tchem
Novelty:  0.00090917
Score:  0.857
Data Source:  STRINGDB
ASB10
Tbio
Novelty:  0.08667666
Score:  0.754
Data Source:  STRINGDB
TMCO1
Tbio
Novelty:  0.04473381
Score:  0.688
Data Source:  STRINGDB
LTBP2
Tbio
Novelty:  0.013159
Score:  0.684
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.675
Data Source:  STRINGDB
TMTC1
Tbio
Novelty:  0.0063204
Score:  0.66
Data Source:  STRINGDB
PEX5
Tbio
Novelty:  0.00560901
Score:  0.641
Data Source:  STRINGDB
CRYBB1
Tbio
Novelty:  0.01083645
Score:  0.627
Data Source:  STRINGDB
Publication Statistics
PubMed Score  782.61

PubMed score by year
PubTator Score  490.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: