Tbio ADAM2 Disintegrin and metalloproteinase domain-containing protein 2

Protein Summary

Description

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q99965
• P78326
• Q9UQQ8
• ADAM 2

Gene Name

• ADAM2

Ensembl ID

• ENST00000265708
• ENSP00000265708
• ENSG00000104755
• ENST00000347580
• ENSP00000343854
• ENST00000613160
• ENSP00000484999
• ENSG00000276286
• ENST00000620181
• ENSP00000482337

Symbol

• FTNB
• CT15
• FTNB
• PH30
• CRYN1
• CRYN2
• PH-30b
• PH30-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
gene perturbation	0.73
molecular function	0.7
cell type or tissue	0.68
cell line	0.65

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Disintegrin And Metalloproteinase Domain-containing Protein 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Disintegrin And Metalloproteinase Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.93   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.93   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0