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Tbio
SH3GL3
Endophilin-A3

Protein Summary
Description
Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324537
  • ENSP00000320092
  • ENSG00000140600
  • ENST00000427482
  • ENSP00000391372

Symbol
  • CNSA3
  • SH3D2C
  • CNSA3
  • EEN-B2
  • SH3D2C
  • SH3P13
  • HsT19371
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
histone modification site profile
0.7
disease perturbation
0.68
protein domain
0.58
PubMedID
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.86   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.86   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
92.5
body height
1
1
1
84.1
FEV/FEC ratio
1
1
1
70
forced expiratory volume
1
1
1
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
92.5
body height
1
84.1
FEV/FEC ratio
1
70
forced expiratory volume
1
59.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like 3, endophilin A3
VGNC:10262
453602
Macaque
SH3 domain containing GRB2 like 3, endophilin A3
718542
Mouse
MGI:700011
20408
Rat
RGD:620578
81921
Dog
SH3 domain containing GRB2 like 3, endophilin A3
VGNC:46126
609858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like 3, endophilin A3
Macaque
SH3 domain containing GRB2 like 3, endophilin A3
Mouse
Rat
Dog
SH3 domain containing GRB2 like 3, endophilin A3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99963-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Disease
Reactome
EGFR downregulation
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Disease
EGFR downregulation
Infectious disease
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (184)
1 – 10 of 184
SH3GL2
Tbio
Novelty: 0.0188955
p_int: 1
Score: 0.992
Data Source: BioPlex,STRINGDB
ARHGAP8
Tbio
Family: Enzyme
Novelty: 0.22016818
p_int: 0.999999779
p_ni: 2.21e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
SH3GL1
Tbio
Novelty: 0.02379336
p_int: 0.999999324
p_ni: 6.76e-7
Score: 0.985
Data Source: BioPlex,STRINGDB
NCF1B
Tdark
p_int: 0.960582415
p_ni: 0.039176935
p_wrong: 0.000240651
Data Source: BioPlex
SGIP1
Tbio
Novelty: 0.09142018
Score: 0.992
Data Source: STRINGDB
DNM2
Tchem
Novelty: 0.00265965
Score: 0.979
Data Source: STRINGDB
SYNJ1
Tbio
Novelty: 0.01030746
Score: 0.976
Data Source: STRINGDB
DNM3
Tbio
Novelty: 0.02365643
Score: 0.973
Data Source: STRINGDB
DNM1
Tbio
Novelty: 0.00319082
Score: 0.97
Data Source: STRINGDB
AMPH
Tbio
Novelty: 0.00201043
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.86

PubMed score by year
PubTator Score  8.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer