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Tbio
SH3GL2
Endophilin-A1

Protein Summary
Description
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380607
  • ENSP00000369981
  • ENSG00000107295

Symbol
  • CNSA2
  • SH3D2A
  • CNSA2
  • SH3P4
  • EEN-B1
  • SH3D2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
trait
0.93
interacting protein
0.81
PubMedID
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.5   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.5   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.1
68.5
mathematical ability
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
68.5
mathematical ability
1
2.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like 2, endophilin A1
VGNC:10449
465008
Macaque
SH3 domain containing GRB2 like 2, endophilin A1
713393
Mouse
MGI:700009
20404
Rat
RGD:620276
116743
Dog
SH3 domain containing GRB2 like 2, endophilin A1
VGNC:46125
611239
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 domain containing GRB2 like 2, endophilin A1
Macaque
SH3 domain containing GRB2 like 2, endophilin A1
Mouse
Rat
Dog
SH3 domain containing GRB2 like 2, endophilin A1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99962-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Developmental Biology
Gene Ontology Terms (35)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (312)
1 – 10 of 312
SH3GL3
Tbio
Novelty:  0.05467913
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
SH3GL1
Tbio
Novelty:  0.02379336
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
ARHGAP8
Tbio
Family:  Enzyme
Novelty:  0.22016818
p_int:  0.999997009
p_ni:  0.000002967
p_wrong:  2.4e-8
Data Source:  BioPlex
TANGO2
Tbio
Novelty:  0.06426374
p_int:  0.999626055
p_ni:  0.000373941
p_wrong:  4e-9
Score:  0.689
Data Source:  BioPlex,STRINGDB
AZU1
Tbio
Family:  Enzyme
Novelty:  0.00267169
p_int:  0.995734962
p_ni:  0.004265016
p_wrong:  2.2e-8
Score:  0.689
Data Source:  BioPlex,STRINGDB
AMPH
Tbio
Novelty:  0.00201043
Score:  0.987
Data Source:  STRINGDB
SYNJ1
Tchem
Novelty:  0.01030746
Score:  0.987
Data Source:  STRINGDB
DNM1
Tbio
Novelty:  0.00319082
Score:  0.981
Data Source:  STRINGDB
DNM3
Tbio
Novelty:  0.02365643
Score:  0.973
Data Source:  STRINGDB
SNAP91
Tbio
Novelty:  0.0083886
Score:  0.973
Data Source:  STRINGDB
Publication Statistics
PubMed Score  51.50

PubMed score by year
PubTator Score  37.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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