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Tbio
PKP2
Plakophilin-2

Protein Summary
Description
May play a role in junctional plaques. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000070846
  • ENSP00000070846
  • ENSG00000057294
  • ENST00000340811
  • ENSP00000342800

Symbol
  • ARVD9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.81
biological process
0.79
virus perturbation
0.76
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.7   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.7   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
83.6
periodontal measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
83.6
periodontal measurement
1
38.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred by Curator (IC)
BHF-UCL
Protein-Protein Interactions (150)
1 – 10 of 150
GRN
Tbio
Novelty: 0.00096395
p_int: 0.997709132
p_ni: 0.002290867
p_wrong: 1e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.993793234
p_ni: 0.006206766
Data Source: BioPlex
TACR1
Tclin
Family: GPCR
Novelty: 0.00062762
p_int: 0.992332758
p_ni: 0.007667242
Data Source: BioPlex
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.992154136
p_ni: 0.007845864
Data Source: BioPlex
TMEM52B
Tdark
Novelty: 1.55824039
p_int: 0.991410991
p_ni: 0.008589009
Data Source: BioPlex
LPAR6
Tchem
Family: GPCR
Novelty: 0.01801122
p_int: 0.99084065
p_ni: 0.00915935
Data Source: BioPlex
KIR2DL1
Tbio
Novelty: 0.00523657
p_int: 0.987225521
p_ni: 0.012774479
Data Source: BioPlex
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
p_int: 0.985523095
p_ni: 0.014476905
Data Source: BioPlex
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.958358177
p_ni: 0.041641381
p_wrong: 4.43e-7
Data Source: BioPlex
EFNB2
Tbio
Novelty: 0.00255095
p_int: 0.93141141
p_ni: 0.06858859
Score: 0.203
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  229.70

PubMed score by year
PubTator Score  158.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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