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Tbio
PKP2
Plakophilin-2

Protein Summary
Description
May play a role in junctional plaques. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000070846
  • ENSP00000070846
  • ENSG00000057294
  • ENST00000340811
  • ENSP00000342800

Symbol
  • ARVD9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.81
biological process
0.79
virus perturbation
0.76
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.01   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.01   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
GRN
Tbio
Novelty:  0.00096395
p_int:  0.997709132
p_ni:  0.002290867
p_wrong:  1e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.993793234
p_ni:  0.006206766
Data Source:  BioPlex
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.992332758
p_ni:  0.007667242
Data Source:  BioPlex
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.992154136
p_ni:  0.007845864
Data Source:  BioPlex
TMEM52B
Tdark
Novelty:  1.55824039
p_int:  0.991410991
p_ni:  0.008589009
Data Source:  BioPlex
LPAR6
Tchem
Family:  GPCR
Novelty:  0.01801122
p_int:  0.99084065
p_ni:  0.00915935
Data Source:  BioPlex
KIR2DL1
Tbio
Novelty:  0.00523657
p_int:  0.987225521
p_ni:  0.012774479
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.985523095
p_ni:  0.014476905
Data Source:  BioPlex
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.958358177
p_ni:  0.041641381
p_wrong:  4.43e-7
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.93141141
p_ni:  0.06858859
Score:  0.203
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred by Curator (IC)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
81.6
3
2
0
1.1
78.2
platelet count
1
1
1
31.4
periodontal measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
81.6
0
1.1
78.2
platelet count
1
31.4
periodontal measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plakophilin 2
VGNC:5531
465265
Macaque
plakophilin 2
100429378
Mouse
MGI:1914701
67451
Dog
plakophilin 2
VGNC:44616
486613
Horse
plakophilin 2
VGNC:21502
100070065
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plakophilin 2
Macaque
plakophilin 2
Mouse
Dog
plakophilin 2
Horse
plakophilin 2
Publication Statistics
PubMed Score 245.01
PubMed score by year
PubTator Score 158.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title