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Tbio
DUSP9
Dual specificity protein phosphatase 9

Protein Summary
Description
Inactivates MAP kinases. Has a specificity for the ERK family. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342782
  • ENSP00000345853
  • ENSG00000130829
  • ENST00000370167
  • ENSP00000359186

Symbol
  • MKP4
  • MKP4
  • MKP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.84
PubMedID
0.71
disease perturbation
0.68
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
79.6
HbA1c measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
79.6
HbA1c measurement
1
36.9
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (55)
1 – 10 of 55
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999999985
p_ni: 4e-9
p_wrong: 1.1e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
DUSP7
Tbio
Family: Enzyme
Novelty: 0.05499898
p_int: 0.999999902
p_wrong: 9.8e-8
Score: 0.903
Data Source: BioPlex,STRINGDB
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.99999353
p_ni: 0.000006469
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.98
Data Source: Reactome,STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.977
Data Source: Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.956
Data Source: STRINGDB
DUSP8
Tbio
Family: Enzyme
Novelty: 0.0105002
Score: 0.917
Data Source: STRINGDB
DUSP4
Tbio
Family: Enzyme
Novelty: 0.00952421
Score: 0.911
Data Source: STRINGDB
DUSP1
Tchem
Family: Enzyme
Novelty: 0.00097955
Score: 0.911
Data Source: STRINGDB
DUSP2
Tbio
Family: Enzyme
Novelty: 0.03459749
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.12

PubMed score by year
PubTator Score  15.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer