PTPN18
Tyrosine-protein phosphatase non-receptor type 18
Protein Summary
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
- ENST00000175756
- ENSP00000175756
- ENSG00000072135
- ENST00000347849
- ENSP00000310092
- BDP1
- BDP1
- PTP-HSCF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
drug perturbation | 0.87 | ||
kinase perturbation | 0.84 | ||
histone modification site profile | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.7 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.7 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (32)
Nearest Tclin Targets
Pathways (12)
Reactome (9)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Downregulation of ERBB2 signaling | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-1 family signaling | ||||
Reactome | Interleukin-37 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Downregulation of ERBB2 signaling | ||||
Immune System | ||||
Interleukin-1 family signaling | ||||
Interleukin-37 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protein tyrosine phosphatase, non-receptor type 18 | VGNC:14773 | 742422 | |||||
Macaque | protein tyrosine phosphatase, non-receptor type 18 | 702266 | ||||||
Mouse | MGI:108410 | 19253 | ||||||
Rat | RGD:1311586 | 301333 | ||||||
Horse | protein tyrosine phosphatase, non-receptor type 18 | VGNC:22015 | 100067347 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protein tyrosine phosphatase, non-receptor type 18 | |||||
Macaque | protein tyrosine phosphatase, non-receptor type 18 | |||||
Mouse | ||||||
Rat | ||||||
Horse | protein tyrosine phosphatase, non-receptor type 18 | |||||
Publication Statistics
PubMed Score 10.70
PubMed score by year
PubTator Score 6.69
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (4)
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