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Tbio
PTPN18
Tyrosine-protein phosphatase non-receptor type 18

Protein Summary
Description
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000175756
  • ENSP00000175756
  • ENSG00000072135
  • ENST00000347849
  • ENSP00000310092

Symbol
  • BDP1
  • BDP1
  • PTP-HSCF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
disease perturbation
0.87
drug perturbation
0.87
kinase perturbation
0.84
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Downregulation of ERBB2 signaling
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-37 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Downregulation of ERBB2 signaling
Immune System
Interleukin-1 family signaling
Interleukin-37 signaling
Protein-Protein Interactions (32)
1 – 10 of 32
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.971
Data Source: Reactome,STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.949
Data Source: Reactome,STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.912
Data Source: Reactome,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.901
Data Source: STRINGDB
IL37
Tbio
Novelty: 0.00499186
Score: 0.9
Data Source: STRINGDB
PSTPIP1
Tbio
Family: Enzyme
Novelty: 0.0114281
Score: 0.876
Data Source: STRINGDB
INSRR
Tchem
Family: Kinase
Novelty: 0.00576355
Score: 0.737
Data Source: STRINGDB
CSK
Tchem
Family: Kinase
Novelty: 0.00186612
Score: 0.716
Data Source: STRINGDB
PSTPIP2
Tbio
Family: Enzyme
Novelty: 0.05122819
Score: 0.671
Data Source: STRINGDB
PTS
Tbio
Family: Enzyme
Novelty: 0.00279396
Score: 0.655
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.20

PubMed score by year
PubTator Score  6.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer