Pharos : Target Details

Tbio

Protein Summary

Description

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

Gene Name

PTPN18

Ensembl ID

ENST00000175756
ENSP00000175756
ENSG00000072135
ENST00000347849
ENSP00000310092

Symbol

BDP1
BDP1
PTP-HSCF

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88

disease perturbation	0.87

drug perturbation	0.87

kinase perturbation	0.84

histone modification site profile	0.81

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.7 (req: < 5)

View Publications

Gene RIFs: 4 (req: <= 3)

View Gene RIFs

Antibodies: 107 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.7 (req: >= 5)

Gene RIFs: 4 (req: > 3)

Antibodies: 107 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Protein-Protein Interactions (32)

1 – 10 of 32

See Interactions on String-DB

ERBB2

Tclin

Family: Kinase

Novelty: 0.00003761

Score: 0.971

Data Source: Reactome,STRINGDB

EGFR

Tclin

Family: Kinase

Novelty: 0.00007274

Score: 0.949

Data Source: Reactome,STRINGDB

EGF

Tbio

Novelty: 0.00010809

Score: 0.912

Data Source: Reactome,STRINGDB

SMAD3

Tchem

Family: TF

Novelty: 0.00048058

Score: 0.901

Data Source: STRINGDB

IL37

Tbio

Novelty: 0.00499186

Score: 0.9

Data Source: STRINGDB

PSTPIP1

Tbio

Family: Enzyme

Novelty: 0.0114281

Score: 0.876

Data Source: STRINGDB

INSRR

Tchem

Family: Kinase

Novelty: 0.00576355

Score: 0.737

Data Source: STRINGDB

CSK

Tchem

Family: Kinase

Novelty: 0.00186612

Score: 0.716

Data Source: STRINGDB

PSTPIP2

Tbio

Family: Enzyme

Novelty: 0.05122819

Score: 0.671

Data Source: STRINGDB

PTS

Tbio

Family: Enzyme

Novelty: 0.00279396

Score: 0.655

Data Source: STRINGDB

Pathways (12)

Reactome (9)

PathwayCommons (2)

WikiPathways (1)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	Downregulation of ERBB2 signaling	29 targets	R-HSA-8863795

Reactome	Immune System	2246 targets	R-HSA-168256

Reactome	Interleukin-1 family signaling	140 targets	R-HSA-446652

Reactome	Interleukin-37 signaling	21 targets	R-HSA-9008059

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Downregulation of ERBB2 signaling	29 targets	R-HSA-8863795

Immune System	2246 targets	R-HSA-168256

Interleukin-1 family signaling	140 targets	R-HSA-446652

Interleukin-37 signaling	21 targets	R-HSA-9008059

Gene Ontology Terms (9)

Functions (2)

Components (2)

Processes (5)

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
protein tyrosine phosphatase activity	Inferred from Experiment (EXP)	Reactome

non-membrane spanning protein tyrosine phosphatase activity	Traceable Author Statement (TAS)	ProtInc

Find similar targets by:

UniProt Keyword

No Header	No Header
3D-structure

Alternative splicing

Complete proteome

Cytoplasm

Hydrolase

Nucleus

Phosphoprotein

Polymorphism

Protein phosphatase

Reference proteome

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID
Chimp	protein tyrosine phosphatase, non-receptor type 18	VGNC:14773	742422

Macaque	protein tyrosine phosphatase, non-receptor type 18		702266

Mouse	protein tyrosine phosphatase, non-receptor type 18	MGI:108410	19253

Rat	protein tyrosine phosphatase, non-receptor type 18	RGD:1311586	301333

Horse	protein tyrosine phosphatase, non-receptor type 18	VGNC:22015	100067347

Species	Name	OMA	EggNOG	Inparanoid
Chimp	protein tyrosine phosphatase, non-receptor type 18

Macaque	protein tyrosine phosphatase, non-receptor type 18

Mouse	protein tyrosine phosphatase, non-receptor type 18

Rat	protein tyrosine phosphatase, non-receptor type 18

Horse	protein tyrosine phosphatase, non-receptor type 18

Publication Statistics

PubMed Score 10.70

PubMed score by year

PubTator Score 6.69

PubTator score by year