Tbio PTPN18 Tyrosine-protein phosphatase non-receptor type 18

Protein Summary

Description

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• Q99952
• B4E1E6
• Q53P42

Gene Name

• PTPN18

Ensembl ID

• ENST00000175756
• ENSP00000175756
• ENSG00000072135
• ENST00000347849
• ENSP00000310092

Symbol

• BDP1
• BDP1
• PTP-HSCF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
disease perturbation	0.87
drug perturbation	0.87
kinase perturbation	0.84
histone modification site profile	0.81

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.2   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.2   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (12)

Reactome (9)

PathwayCommons (2)

WikiPathways (1)

Cytokine Signaling in Immune system (R-HSA-1280215)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Downregulation of ERBB2 signaling	29 targets	R-HSA-8863795
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-1 family signaling	140 targets	R-HSA-446652
Reactome	Interleukin-37 signaling	21 targets	R-HSA-9008059

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Downregulation of ERBB2 signaling	29 targets	R-HSA-8863795
Immune System	2246 targets	R-HSA-168256
Interleukin-1 family signaling	140 targets	R-HSA-446652
Interleukin-37 signaling	21 targets	R-HSA-9008059

Gene Ontology Terms (9)

Functions (2)

Components (2)

Processes (5)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
protein tyrosine phosphatase activity	Inferred from Experiment (EXP)	Reactome
non-membrane spanning protein tyrosine phosphatase activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (32)

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1 – 10 of 32

• See Interactions on String-DB

ERBB2

Tclin

Family: Kinase

Novelty: 0.00003761

Score: 0.971

Data Source: Reactome,STRINGDB

EGFR

Tclin

Family: Kinase

Novelty: 0.00007274

Score: 0.949

Data Source: Reactome,STRINGDB

EGF

Tbio

Novelty: 0.00010809

Score: 0.912

Data Source: Reactome,STRINGDB

SMAD3

Tbio

Family: TF

Novelty: 0.00048058

Score: 0.901

Data Source: STRINGDB

IL37

Tbio

Novelty: 0.00499186

Score: 0.9

Data Source: STRINGDB

PSTPIP1

Tbio

Family: Enzyme

Novelty: 0.0114281

Score: 0.876

Data Source: STRINGDB

INSRR

Tchem

Family: Kinase

Novelty: 0.00576355

Score: 0.737

Data Source: STRINGDB

CSK

Tchem

Family: Kinase

Novelty: 0.00186612

Score: 0.716

Data Source: STRINGDB

PSTPIP2

Tbio

Family: Enzyme

Novelty: 0.05122819

Score: 0.671

Data Source: STRINGDB

PTS

Tbio

Family: Enzyme

Novelty: 0.00279396

Score: 0.655

Data Source: STRINGDB

Publication Statistics

PubMed Score  10.20

PubMed score by year

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PubTator Score  6.69

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Nucleus
Phosphoprotein
Polymorphism
Protein phosphatase
Reference proteome