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Tbio
AGPAT1
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

Protein Summary
Description
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336984
  • ENSP00000337463
  • ENSG00000204310
  • ENST00000375104
  • ENSP00000364245
  • ENST00000375107
  • ENSP00000364248
  • ENST00000383294
  • ENSP00000372782
  • ENSG00000206324
  • ENST00000395496
  • ENSP00000378874
  • ENST00000395497
  • ENSP00000378875
  • ENST00000395499
  • ENSP00000378877
  • ENST00000399825
  • ENSP00000382721
  • ENST00000399827
  • ENSP00000382723
  • ENST00000399829
  • ENSP00000382725
  • ENST00000399830
  • ENSP00000382726
  • ENST00000399833
  • ENSP00000382728
  • ENST00000414520
  • ENSP00000406615
  • ENSG00000227642
  • ENST00000414933
  • ENSP00000388870
  • ENST00000415173
  • ENSP00000412805
  • ENSG00000228892
  • ENST00000416363
  • ENSP00000407189
  • ENSG00000236873
  • ENST00000417388
  • ENSP00000415015
  • ENST00000424030
  • ENSP00000397765
  • ENST00000425204
  • ENSP00000388253
  • ENSG00000226467
  • ENST00000425572
  • ENSP00000394919
  • ENSG00000235758
  • ENST00000427763
  • ENSP00000401410
  • ENST00000430226
  • ENSP00000412304
  • ENST00000430777
  • ENSP00000392820
  • ENST00000433376
  • ENSP00000387810
  • ENST00000433896
  • ENSP00000408842
  • ENST00000434614
  • ENSP00000401287
  • ENST00000436149
  • ENSP00000388090
  • ENST00000439774
  • ENSP00000398016
  • ENST00000440840
  • ENSP00000395863
  • ENST00000444369
  • ENSP00000408032
  • ENST00000446323
  • ENSP00000392083
  • ENST00000446463
  • ENSP00000405864
  • ENST00000448196
  • ENSP00000404106
  • ENST00000449776
  • ENSP00000410831
  • ENST00000451833
  • ENSP00000406582
  • ENST00000452393
  • ENSP00000406614
  • ENST00000452427
  • ENSP00000387738
  • ENST00000454929
  • ENSP00000390988
  • ENST00000455898
  • ENSP00000395613
  • ENST00000456421
  • ENSP00000389516
  • ENST00000456679
  • ENSP00000388815
  • ENST00000457923
  • ENSP00000405565

Symbol
  • G15
  • G15
  • LPAATA
  • 1-AGPAT1
  • LPAAT-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor binding site profile
0.83
transcription factor
0.82
gene perturbation
0.81
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (34)
ChREBP activates metabolic gene expression (R-HSA-163765)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ChREBP activates metabolic gene expression
Reactome
Glycerophospholipid biosynthesis
Reactome
Integration of energy metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
ChREBP activates metabolic gene expression
Glycerophospholipid biosynthesis
Integration of energy metabolism
Metabolism
Metabolism of lipids
Protein-Protein Interactions (111)
1 – 10 of 111
RNASEH2A
Tbio
Family: Enzyme
Novelty: 0.00612887
p_int: 0.980864772
p_ni: 0.019135227
Score: 0.383
Data Source: BioPlex,STRINGDB
HAVCR2
Tbio
Novelty: 0.00217571
p_int: 0.919378442
p_ni: 0.080621558
Data Source: BioPlex
C5AR2
Tbio
Family: GPCR
Novelty: 0.01354267
p_int: 0.803045016
p_ni: 0.196954983
p_wrong: 1e-9
Data Source: BioPlex
TNFRSF17
Tbio
Novelty: 0.00587499
p_int: 0.761330869
p_ni: 0.238669122
p_wrong: 9e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
MBOAT2
Tbio
Family: Enzyme
Novelty: 0.03587281
Score: 0.978
Data Source: STRINGDB
GPAM
Tbio
Family: Enzyme
Novelty: 0.00895841
Score: 0.978
Data Source: STRINGDB
GPAT3
Tbio
Family: Enzyme
Novelty: 0.05392755
Score: 0.973
Data Source: STRINGDB
GPAT4
Tbio
Family: Enzyme
Novelty: 0.04994969
Score: 0.972
Data Source: STRINGDB
GPAT2
Tbio
Family: Enzyme
Novelty: 0.0514769
Score: 0.961
Data Source: STRINGDB
CDS1
Tbio
Family: Enzyme
Novelty: 0.06388642
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.78

PubMed score by year
PubTator Score  17.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer