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Tbio
RNF5
E3 ubiquitin-protein ligase RNF5

Protein Summary
Description
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375094
  • ENSP00000364235
  • ENSG00000204308
  • ENST00000413786
  • ENSP00000387879
  • ENSG00000225452
  • ENST00000432616
  • ENSP00000413131
  • ENSG00000183574
  • ENST00000445885
  • ENSP00000401172
  • ENSG00000227277
  • ENST00000449794
  • ENSP00000415784
  • ENSG00000223767
  • ENST00000453473
  • ENSP00000415127
  • ENSG00000228907
  • ENST00000456167
  • ENSP00000388795
  • ENSG00000228405

Symbol
  • G16
  • NG2
  • RMA1
  • RMA1
  • RING5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.85
cellular component
0.76
biological process
0.62
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.74   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.74   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (539)
Items per page:
1 – 5 of 539
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
complement C4 measurement
2
4
7
97.4
Items per page:
1 – 5 of 539
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
complement C4 measurement
7
97.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1860076
54197
Rat
RGD:1588458
407784
Dog
ring finger protein 5
VGNC:45673
474858
Horse
ring finger protein 5
VGNC:22484
100051626
Cow
ring finger protein 5
VGNC:34070
616187
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ring finger protein 5
Horse
ring finger protein 5
Cow
ring finger protein 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99942-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Defective CFTR causes cystic fibrosis
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Defective CFTR causes cystic fibrosis
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (116)
1 – 10 of 116
RHBDD1
Tbio
Family:  Enzyme
Novelty:  0.10354568
p_int:  0.995495641
p_ni:  0.004496993
p_wrong:  0.000007365
Score:  0.185
Data Source:  BioPlex,STRINGDB
GOLM1
Tbio
Novelty:  0.00752112
p_int:  0.97784602
p_ni:  0.02215387
p_wrong:  1.1e-7
Data Source:  BioPlex
ST7L
Tbio
Novelty:  0.03661324
p_int:  0.973555047
p_ni:  0.026310445
p_wrong:  0.000134508
Data Source:  BioPlex
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.847760842
p_ni:  0.151310194
p_wrong:  0.000928964
Data Source:  BioPlex
CYHR1
Tdark
Novelty:  0.04771996
p_int:  0.803273726
p_ni:  0.000034394
p_wrong:  0.19669188
Data Source:  BioPlex
TMEM259
Tbio
Novelty:  0.10015777
p_int:  0.800195233
p_ni:  0.199804767
Score:  0.188
Data Source:  BioPlex,STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.982
Data Source:  STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
Score:  0.977
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.97
Data Source:  STRINGDB
DERL2
Tbio
Novelty:  0.02479307
Score:  0.959
Data Source:  STRINGDB
Publication Statistics
PubMed Score  35.74

PubMed score by year
PubTator Score  27.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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