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Tbio
RNF5
E3 ubiquitin-protein ligase RNF5

Protein Summary
Description
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375094
  • ENSP00000364235
  • ENSG00000204308
  • ENST00000413786
  • ENSP00000387879
  • ENSG00000225452
  • ENST00000432616
  • ENSP00000413131
  • ENSG00000183574
  • ENST00000445885
  • ENSP00000401172
  • ENSG00000227277
  • ENST00000449794
  • ENSP00000415784
  • ENSG00000223767
  • ENST00000453473
  • ENSP00000415127
  • ENSG00000228907
  • ENST00000456167
  • ENSP00000388795
  • ENSG00000228405

Symbol
  • G16
  • NG2
  • RMA1
  • RMA1
  • RING5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.85
cellular component
0.76
biological process
0.62
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.33   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.33   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0