Tbio RNF5 E3 ubiquitin-protein ligase RNF5

Protein Summary

Description

Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses. The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99942
• A2BFI6
• B2R4K3
• Q0VDB7
• Q9UMQ2

Gene Name

• RNF5

Ensembl ID

• ENST00000375094
• ENSP00000364235
• ENSG00000204308
• ENST00000413786
• ENSP00000387879
• ENSG00000225452
• ENST00000432616
• ENSP00000413131
• ENSG00000183574
• ENST00000445885
• ENSP00000401172
• ENSG00000227277
• ENST00000449794
• ENSP00000415784
• ENSG00000223767
• ENST00000453473
• ENSP00000415127
• ENSG00000228907
• ENST00000456167
• ENSP00000388795
• ENSG00000228405

Symbol

• G16
• NG2
• RMA1
• RMA1
• RING5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
virus perturbation	0.85
cellular component	0.76
biological process	0.62
trait	0.61

Protein Classes

PANTHER Classes

Protein / ... / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Rnf5

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Rnf5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.33   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.33   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0