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Tbio
ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

Protein Summary
Description
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293709
  • ENSP00000293709
  • ENSG00000168468
  • ENST00000375201
  • ENSP00000364347
  • ENSG00000213676
  • ENST00000375203
  • ENSP00000364349
  • ENST00000383156
  • ENSP00000372642
  • ENST00000425571
  • ENSP00000404814
  • ENSG00000228628
  • ENST00000427136
  • ENSP00000404725
  • ENSG00000234539
  • ENST00000435768
  • ENSP00000399764
  • ENST00000439240
  • ENSP00000391131

Symbol
  • CREBL1
  • G13
  • G13
  • CREBL1
  • CREB-RP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
cellular component
0.67
tissue sample
0.62
cell line
0.61
biological process
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.26   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.26   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (123)
RWDD2B
Tdark
Novelty:  0.42452529
p_int:  0.999997818
p_ni:  0.000002182
Score:  0.169
Data Source:  BioPlex,STRINGDB
IL7
Tbio
Novelty:  0.00054101
p_int:  0.997115683
p_ni:  0.002884317
Data Source:  BioPlex
TBC1D15
Tbio
Novelty:  0.11296513
p_int:  0.996889312
p_ni:  0.003110688
Data Source:  BioPlex
TEX15
Tbio
Novelty:  0.08059572
p_int:  0.995407192
p_ni:  0.000353723
p_wrong:  0.004239085
Score:  0.221
Data Source:  BioPlex,STRINGDB
OXSM
Tbio
Family:  Enzyme
Novelty:  0.00615894
p_int:  0.994487228
p_ni:  0.00139083
p_wrong:  0.004121942
Score:  0.189
Data Source:  BioPlex,STRINGDB
AK4
Tbio
Family:  Kinase
Novelty:  0.00977619
p_int:  0.97925853
p_ni:  0.020741469
p_wrong:  1e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty:  0.04851082
p_int:  0.95371194
p_ni:  0.036858888
p_wrong:  0.009429172
Score:  0.256
Data Source:  BioPlex,STRINGDB
OS9
Tbio
Novelty:  0.01490339
p_int:  0.950202722
p_ni:  0.049797278
Data Source:  BioPlex
ERLEC1
Tbio
Novelty:  0.01243855
p_int:  0.900335626
p_ni:  0.099664372
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.894949456
p_ni:  0.105050544
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (28)
Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
Parathyroid hormone synthesis, secretion and action
KEGG
Cortisol synthesis and secretion
KEGG
Relaxin signaling pathway
KEGG
Aldosterone synthesis and secretion
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
Parathyroid hormone synthesis, secretion and action
Cortisol synthesis and secretion
Relaxin signaling pathway
Aldosterone synthesis and secretion
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (240)
Items per page:
1 – 5 of 240
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
2
6
10
98.5
complement C4 measurement
2
6
10
98.5
complement C4 measurement
2
6
10
98.5
4
3
0
2.3
97.6
4
3
0
2.3
97.6
Items per page:
1 – 5 of 240
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
complement C4 measurement
10
98.5
complement C4 measurement
10
98.5
complement C4 measurement
10
98.5
0
2.3
97.6
0
2.3
97.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:105121
12915
Rat
RGD:1303317
406169
Dog
activating transcription factor 6 beta
VGNC:52104
474855
Horse
activating transcription factor 6 beta
VGNC:15613
100059348
Cow
activating transcription factor 6 beta
VGNC:26245
513928
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
activating transcription factor 6 beta
Horse
activating transcription factor 6 beta
Cow
activating transcription factor 6 beta
Publication Statistics
PubMed Score 11.26
PubMed score by year
PubTator Score 22.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title