Tbio ATF6B Cyclic AMP-dependent transcription factor ATF-6 beta

Protein Summary

Description

Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q99941
• B0UYX6
• Q13269
• Q14343
• Q14345
• Q5SSW7
• Q99635
• Q99637
• Q9H3V9
• Q9H3W1
• Q9NPL0
• cAMP-dependent transcription factor ATF-6 beta

Gene Name

• ATF6B

Ensembl ID

• ENST00000293709
• ENSP00000293709
• ENSG00000168468
• ENST00000375201
• ENSP00000364347
• ENSG00000213676
• ENST00000375203
• ENSP00000364349
• ENST00000383156
• ENSP00000372642
• ENST00000425571
• ENSP00000404814
• ENSG00000228628
• ENST00000427136
• ENSP00000404725
• ENSG00000234539
• ENST00000435768
• ENSP00000399764
• ENST00000439240
• ENSP00000391131

Symbol

• CREBL1
• G13
• G13
• CREBL1
• CREB-RP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
cellular component	0.67
tissue sample	0.62
cell line	0.61
biological process	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.58   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.58   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0