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Tbio
ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

Protein Summary
Description
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE. The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293709
  • ENSP00000293709
  • ENSG00000168468
  • ENST00000375201
  • ENSP00000364347
  • ENSG00000213676
  • ENST00000375203
  • ENSP00000364349
  • ENST00000383156
  • ENSP00000372642
  • ENST00000425571
  • ENSP00000404814
  • ENSG00000228628
  • ENST00000427136
  • ENSP00000404725
  • ENSG00000234539
  • ENST00000435768
  • ENSP00000399764
  • ENST00000439240
  • ENSP00000391131

Symbol
  • CREBL1
  • G13
  • G13
  • CREBL1
  • CREB-RP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
cellular component
0.67
tissue sample
0.62
cell line
0.61
biological process
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.28   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.28   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Löfgren’s syndrome
1
1
0
4.2
94.4
Löfgren’s syndrome
1
1
0
4.2
94.4
Löfgren’s syndrome
1
1
0
4.2
94.4
feeling nervous measurement
1
1
0
6.5
31.9
feeling nervous measurement
1
1
0
6.5
31.9
Items per page:
1 – 5 of 9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Löfgren’s syndrome
0
4.2
94.4
Löfgren’s syndrome
0
4.2
94.4
Löfgren’s syndrome
0
4.2
94.4
feeling nervous measurement
0
6.5
31.9
feeling nervous measurement
0
6.5
31.9
Pathways (28)
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
Parathyroid hormone synthesis, secretion and action
KEGG
Cortisol synthesis and secretion
KEGG
Relaxin signaling pathway
KEGG
Aldosterone synthesis and secretion
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
Parathyroid hormone synthesis, secretion and action
Cortisol synthesis and secretion
Relaxin signaling pathway
Aldosterone synthesis and secretion
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (123)
1 – 10 of 123
RWDD2B
Tdark
Novelty: 0.42452529
p_int: 0.999997818
p_ni: 0.000002182
Score: 0.169
Data Source: BioPlex,STRINGDB
IL7
Tbio
Novelty: 0.00054101
p_int: 0.997115683
p_ni: 0.002884317
Data Source: BioPlex
TBC1D15
Tbio
Novelty: 0.11296513
p_int: 0.996889312
p_ni: 0.003110688
Data Source: BioPlex
TEX15
Tbio
Novelty: 0.08059572
p_int: 0.995407192
p_ni: 0.000353723
p_wrong: 0.004239085
Score: 0.221
Data Source: BioPlex,STRINGDB
OXSM
Tbio
Family: Enzyme
Novelty: 0.00615894
p_int: 0.994487228
p_ni: 0.00139083
p_wrong: 0.004121942
Score: 0.189
Data Source: BioPlex,STRINGDB
AK4
Tbio
Family: Kinase
Novelty: 0.00977619
p_int: 0.97925853
p_ni: 0.020741469
p_wrong: 1e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
PPP1R9A
Tbio
Novelty: 0.04851082
p_int: 0.95371194
p_ni: 0.036858888
p_wrong: 0.009429172
Score: 0.256
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.950202722
p_ni: 0.049797278
Data Source: BioPlex
ERLEC1
Tbio
Novelty: 0.01243855
p_int: 0.900335626
p_ni: 0.099664372
p_wrong: 2e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
EDDM3B
Tdark
Novelty: 0.12874735
p_int: 0.894949456
p_ni: 0.105050544
Data Source: BioPlex
Publication Statistics
PubMed Score  11.28

PubMed score by year
PubTator Score  22.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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