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Tbio
BAG1
BAG family molecular chaperone regulator 1

Protein Summary
Description
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379704
  • ENSP00000369026
  • ENSG00000107262
  • ENST00000641048
  • ENSP00000493185

Symbol
  • HAP
  • HAP
  • BAG-1
  • RAP46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
histone modification site profile
0.89
transcription factor perturbation
0.84
biological term
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.37   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 478   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.37   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 478   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
3
4
91.9
influenza A (H1N1)
3
1
0
21.1
62.1
hemoglobin measurement
1
1
1
48.5
creatinine measurement
1
1
1
38.2
glomerular filtration rate
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
91.9
influenza A (H1N1)
0
21.1
62.1
hemoglobin measurement
1
48.5
creatinine measurement
1
38.2
glomerular filtration rate
1
33.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:108047
12017
Rat
RGD:1305203
297994
Dog
BCL2 associated athanogene 1
VGNC:38363
611781
Cow
BCL2 associated athanogene 1
VGNC:26405
613855
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
BCL2 associated athanogene 1
Cow
BCL2 associated athanogene 1
Protein Structure (26 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99933-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 26
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Protein-Protein Interactions (117)
1 – 10 of 117
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.999823879
p_ni:  0.00017611
p_wrong:  1e-8
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.998955443
p_ni:  0.00102323
p_wrong:  0.000021327
Data Source:  BioPlex
BHLHA15
Tbio
Family:  TF
Novelty:  0.02721846
p_int:  0.998150378
p_ni:  0.001798427
p_wrong:  0.000051195
Data Source:  BioPlex
ZNF385C
Tdark
Novelty:  2.23931637
p_int:  0.993056191
p_ni:  0.006943594
p_wrong:  2.14e-7
Data Source:  BioPlex
SAV1
Tbio
Novelty:  0.00962335
p_int:  0.992430695
p_ni:  0.007567139
p_wrong:  0.000002165
Score:  0.177
Data Source:  BioPlex,STRINGDB
PRDM5
Tbio
Family:  TF; Epigenetic
Novelty:  0.01689997
p_int:  0.992070826
p_ni:  0.007927827
p_wrong:  0.000001347
Data Source:  BioPlex
YY1AP1
Tbio
Novelty:  0.06862573
p_int:  0.986342762
p_ni:  0.01365717
p_wrong:  6.8e-8
Score:  0.222
Data Source:  BioPlex,STRINGDB
GTF3C2
Tdark
Novelty:  0.1827844
p_int:  0.975220822
p_ni:  0.02477887
p_wrong:  3.08e-7
Data Source:  BioPlex
KCND2
Tclin
Family:  IC
Novelty:  0.00297203
p_int:  0.974112209
p_ni:  0.025887731
p_wrong:  6e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
PSMC1
Tbio
Family:  Enzyme
Novelty:  0.04631888
p_int:  0.971735351
p_ni:  0.028264441
p_wrong:  2.08e-7
Score:  0.722
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  377.37

PubMed score by year
PubTator Score  236.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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