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Tbio
SPAG8
Sperm-associated antigen 8

Protein Summary
Description
Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252). The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recog ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340291
  • ENSP00000340982
  • ENSG00000137098
  • ENST00000396638
  • ENSP00000379878
  • ENST00000475644
  • ENSP00000418530

Symbol
  • SMP1
  • BS-84
  • CT142
  • HSD-1
  • SPAG3
  • CILD28
  • hSMP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.62
transcription factor binding site profile
0.56
cell line
0.51
small molecule perturbation
0.51
histone modification site profile
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sperm associated antigen 8
VGNC:4868
746986
Macaque
sperm associated antigen 8
695859
Mouse
MGI:3056295
433700
Rat
RGD:1307079
362508
Dog
sperm associated antigen 8
VGNC:46698
102152667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sperm associated antigen 8
Macaque
sperm associated antigen 8
Mouse
Rat
Dog
sperm associated antigen 8
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (34)
1 – 10 of 34
FBXO39
Tbio
Novelty: 0.05342001
Score: 0.818
Data Source: STRINGDB
SPAG17
Tdark
Novelty: 0.03260168
Score: 0.671
Data Source: STRINGDB
PRSS55
Tbio
Family: Enzyme
Novelty: 0.20503445
Score: 0.643
Data Source: STRINGDB
ACSM3
Tbio
Family: Enzyme
Novelty: 0.02440917
Score: 0.634
Data Source: STRINGDB
RANBP9
Tbio
Novelty: 0.02182372
Score: 0.63
Data Source: STRINGDB
CT45A6
Tdark
Novelty: 0.32451689
Score: 0.579
Data Source: STRINGDB
CCNDBP1
Tbio
Novelty: 0.01527762
Score: 0.566
Data Source: STRINGDB
GOLGA6L2
Tdark
Novelty: 0.05996778
Score: 0.543
Data Source: STRINGDB
CRISPLD1
Tbio
Novelty: 0.10131944
Score: 0.54
Data Source: STRINGDB
LCN8
Tbio
Novelty: 0.02098116
Score: 0.531
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.75

PubMed score by year
PubTator Score  19.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer