You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GABRG3
Gamma-aminobutyric acid receptor subunit gamma-3

Protein Classes
Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000555083
  • ENSP00000452244
  • ENSG00000182256
  • ENST00000615808
  • ENSP00000479113
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
protein domain
0.92
molecular function
0.86
cell type or tissue
0.81
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.08   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.08   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17
Approved Drugs (17)
1 – 10 of 17
halothane
chemical structure image
isoflurane
chemical structure image
desflurane
chemical structure image
sevoflurane
chemical structure image
methoxyflurane
chemical structure image
metharbital
chemical structure image
talbutal
chemical structure image
triclofos
chemical structure image
thiamylal
chemical structure image
halazepam
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
4
91.7
self reported educational attainment
1
1
1
86
cognitive function measurement
1
2
2
83.4
risk-taking behaviour
1
1
1
11.3
Hepatitis
1
1
0
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
91.7
self reported educational attainment
1
86
cognitive function measurement
2
83.4
risk-taking behaviour
1
11.3
Hepatitis
0
1
7.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor gamma3 subunit
720390
Mouse
MGI:95624
14407
Rat
RGD:621735
79211
Horse
gamma-aminobutyric acid type A receptor gamma3 subunit [Source:HGNC Symbol;Acc:HGNC:4088]
Opossum
gamma-aminobutyric acid receptor subunit gamma-3
100011485
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor gamma3 subunit
Mouse
Rat
Horse
gamma-aminobutyric acid type A receptor gamma3 subunit [Source:HGNC Symbol;Acc:HGNC:4088]
Opossum
gamma-aminobutyric acid receptor subunit gamma-3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99928-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (100)
1 – 10 of 100
GABRB3
Tclin
Family: IC
Novelty: 0.00485997
Score: 0.942
Data Source: Reactome,STRINGDB
GABRB1
Tclin
Family: IC
Novelty: 0.02895574
Score: 0.94
Data Source: Reactome,STRINGDB
GABRB2
Tclin
Family: IC
Novelty: 0.01954146
Score: 0.94
Data Source: Reactome,STRINGDB
GABRQ
Tclin
Family: IC
Novelty: 0.12221217
Score: 0.938
Data Source: Reactome,STRINGDB
GABRA5
Tclin
Family: IC
Novelty: 0.01499706
Score: 0.913
Data Source: STRINGDB
GABRA1
Tclin
Family: IC
Novelty: 0.0094079
Score: 0.913
Data Source: Reactome,STRINGDB
GABRA4
Tclin
Family: IC
Novelty: 0.03089903
Score: 0.911
Data Source: STRINGDB
GABRA2
Tclin
Family: IC
Novelty: 0.00663529
Score: 0.911
Data Source: STRINGDB
GABRA6
Tclin
Family: IC
Novelty: 0.02894664
Score: 0.909
Data Source: STRINGDB
ARHGEF9
Tbio
Novelty: 0.01577146
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.08

PubMed score by year
PubTator Score  11.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: