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Tchem
CTRC
Chymotrypsin-C

Protein Summary
Description
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375949
  • ENSP00000365116
  • ENSG00000162438

Symbol
  • CLCR
  • CLCR
  • ELA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
disease perturbation
0.74
gene perturbation
0.58
protein domain
0.58
tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 198.84   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 198.84   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (39)
1 – 10 of 39
CHEMBL76522
Rendered image for CHEMBL76522
CHEMBL296771
Rendered image for CHEMBL296771
CHEMBL457155
Rendered image for CHEMBL457155
CHEMBL102115
Rendered image for CHEMBL102115
Peptide Boronic Acid analogue
Rendered image for Peptide Boronic Acid analogue
CHEMBL100672
Rendered image for CHEMBL100672
CHEMBL11391
Rendered image for CHEMBL11391
CHEMBL113261
Rendered image for CHEMBL113261
Protein-Protein Interactions (42)
1 – 10 of 42
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.928459914
p_ni:  0.07150738
p_wrong:  0.000032706
Score:  0.39
Data Source:  BioPlex,STRINGDB
CPA1
Tchem
Family:  Enzyme
Novelty:  0.00601525
Score:  0.952
Data Source:  STRINGDB
PRSS1
Tclin
Family:  Enzyme
Novelty:  0.00157396
Score:  0.941
Data Source:  Reactome,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.909
Data Source:  STRINGDB
SPINK1
Tbio
Family:  Enzyme
Novelty:  0.00074416
Score:  0.896
Data Source:  STRINGDB
CPB1
Tchem
Family:  Enzyme
Novelty:  0.00108031
Score:  0.877
Data Source:  STRINGDB
CELA3B
Tbio
Family:  Enzyme
Novelty:  0.0039289
Score:  0.819
Data Source:  STRINGDB
CELA3A
Tbio
Family:  Enzyme
Novelty:  0.04100319
Score:  0.779
Data Source:  STRINGDB
CPA2
Tchem
Family:  Enzyme
Novelty:  0.01066441
Score:  0.718
Data Source:  STRINGDB
HTRA1
Tchem
Family:  Enzyme
Novelty:  0.0016879
Score:  0.716
Data Source:  STRINGDB
Pathways (5)
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
5
0
1.6
91.3
urate measurement
2
3
3
87.6
creatinine measurement
4
4
4
84.3
glomerular filtration rate
4
4
4
80.8
body mass index
2
2
2
49.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
91.3
urate measurement
3
87.6
creatinine measurement
4
84.3
glomerular filtration rate
4
80.8
body mass index
2
49.4
Find similar targets by:
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chymotrypsin C
VGNC:6116
739685
Macaque
chymotrypsin C [Source:HGNC Symbol;Acc:HGNC:2523]
Mouse
MGI:1923951
76701
Rat
RGD:1308379
362653
Horse
chymotrypsin C
VGNC:16946
100054423
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chymotrypsin C
Macaque
chymotrypsin C [Source:HGNC Symbol;Acc:HGNC:2523]
Mouse
Rat
Horse
chymotrypsin C
Publication Statistics
PubMed Score 198.84
PubMed score by year
PubTator Score 141.30
PubTator score by year