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Tchem
CTRC
Chymotrypsin-C

Protein Summary
Description
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375949
  • ENSP00000365116
  • ENSG00000162438

Symbol
  • CLCR
  • CLCR
  • ELA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
disease perturbation
0.74
gene perturbation
0.58
protein domain
0.58
tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.67   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.67   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (42)
1 – 10 of 42
SUMF1
Tbio
Family: Enzyme
Novelty: 0.01184153
p_int: 0.928459914
p_ni: 0.07150738
p_wrong: 0.000032706
Score: 0.39
Data Source: BioPlex,STRINGDB
CPA1
Tchem
Family: Enzyme
Novelty: 0.0064154
Score: 0.952
Data Source: STRINGDB
PRSS1
Tclin
Family: Enzyme
Novelty: 0.00182538
Score: 0.941
Data Source: Reactome,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00096649
Score: 0.909
Data Source: STRINGDB
SPINK1
Tbio
Family: Enzyme
Novelty: 0.00089755
Score: 0.896
Data Source: STRINGDB
CPB1
Tchem
Family: Enzyme
Novelty: 0.00097725
Score: 0.877
Data Source: STRINGDB
CELA3B
Tbio
Family: Enzyme
Novelty: 0.00245593
Score: 0.819
Data Source: STRINGDB
CELA3A
Tbio
Family: Enzyme
Novelty: 0.05122055
Score: 0.779
Data Source: STRINGDB
CPA2
Tbio
Family: Enzyme
Novelty: 0.01567464
Score: 0.718
Data Source: STRINGDB
HTRA1
Tbio
Family: Enzyme
Novelty: 0.00171455
Score: 0.716
Data Source: STRINGDB
Publication Statistics
PubMed Score  310.67

PubMed score by year
PubTator Score  141.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer