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Tdark
SPIN2A
Spindlin-2A

Protein Summary
Description
May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846). This gene encodes one of three members of the DXF34 gene family, located in a 100-kb region of chromosome Xp11.21. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374906
  • ENSP00000364041
  • ENSG00000147059
  • ENST00000374908
  • ENSP00000364043

Symbol
  • DXF34
  • SPIN2
  • DXF34
  • SPIN2
  • TDRD25
  • dJ323P24.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
tissue sample
0.56
tissue
0.48
cell line
0.44
chemical
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (6)
1 – 6 of 6
SIPA1L3
Tbio
Novelty:  0.13962558
p_int:  0.999987809
p_ni:  0.000003553
p_wrong:  0.000008637
Data Source:  BioPlex
IL3
Tbio
Novelty:  0.0002336
Score:  0.507
Data Source:  STRINGDB
PCDHGB3
Tdark
Novelty:  1.9379995
Score:  0.44
Data Source:  STRINGDB
CMPK1
Tchem
Family:  Kinase
Novelty:  0.01478492
Score:  0.42
Data Source:  STRINGDB
A1BG
Tbio
Novelty:  0.00508743
Score:  0.42
Data Source:  STRINGDB
RGPD5
Tbio
Novelty:  0.13776125
Score:  0.416
Data Source:  STRINGDB
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
81.6
reticulocyte count
2
1
2
39.6
1
1
0
1.1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
81.6
reticulocyte count
2
39.6
0
1.1
4.1
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
spindlin-2B
100855689
Horse
spindlin-2B
100061997
Species
Name
OMA
EggNOG
Inparanoid
Dog
spindlin-2B
Horse
spindlin-2B
Publication Statistics
PubMed Score 7.54
PubMed score by year
PubTator Score 1011.57
PubTator score by year