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Tbio
MYD88
Myeloid differentiation primary response protein MyD88

Protein Summary
Description
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396334
  • ENSP00000379625
  • ENSG00000172936
  • ENST00000424893
  • ENSP00000389979
  • ENST00000495303
  • ENSP00000417848

Symbol
  • MYD88D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.96
transcription factor binding site profile
0.84
transcription factor perturbation
0.8
disease
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2698.77   (req: < 5)
Gene RIFs: 333   (req: <= 3)
Antibodies: 882   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2698.77   (req: >= 5)
Gene RIFs: 333   (req: > 3)
Antibodies: 882   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
0.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myeloid differentiation primary response 88
VGNC:2434
460269
Macaque
myeloid differentiation primary response 88
696494
Mouse
MGI:108005
17874
Rat
RGD:735043
301059
Dog
myeloid differentiation primary response 88
VGNC:43531
477024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myeloid differentiation primary response 88
Macaque
myeloid differentiation primary response 88
Mouse
Rat
Dog
myeloid differentiation primary response 88
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99836-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (320)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
Protein-Protein Interactions (357)
1 – 10 of 357
SPOP
Tbio
Novelty: 0.00663363
p_int: 0.999998405
p_ni: 0.000001595
Score: 0.545
Data Source: BioPlex,STRINGDB
IRAK2
Tbio
Family: Kinase
Novelty: 0.01496024
Score: 0.999
Data Source: Reactome,STRINGDB
IRAK4
Tchem
Family: Kinase
Novelty: 0.00344058
Score: 0.999
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.999
Data Source: Reactome,STRINGDB
IL1R1
Tclin
Novelty: 0.0014281
Score: 0.999
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.999
Data Source: Reactome,STRINGDB
TLR3
Tbio
Novelty: 0.00057048
Score: 0.997
Data Source: STRINGDB
TLR7
Tclin
Novelty: 0.00067036
Score: 0.995
Data Source: Reactome,STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.995
Data Source: Reactome,STRINGDB
IRAK3
Tchem
Family: Kinase
Novelty: 0.01001206
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  2698.77

PubMed score by year
PubTator Score  964.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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