You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
SMO
Smoothened homolog

Protein Summary
Description
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity). The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249373
  • ENSP00000249373
  • ENSG00000128602

Symbol
  • SMOH
  • Gx
  • CRJS
  • SMOH
  • FZD11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
histone modification site profile
0.84
PubMedID
0.82
phosphatase
0.81
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.18   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.18   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 64
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 287
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
vismodegib
chemical structure image
sonidegib
chemical structure image
glasdegib
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
1
1
0
2.8
60.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
0
2.8
60.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
smoothened, frizzled class receptor
VGNC:4508
463718
Macaque
smoothened, frizzled class receptor
701334
Mouse
MGI:108075
319757
Rat
RGD:3726
25273
Dog
smoothened, frizzled class receptor
VGNC:46565
482262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
smoothened, frizzled class receptor
Macaque
smoothened, frizzled class receptor
Mouse
Rat
Dog
smoothened, frizzled class receptor
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99835-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (52)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Class B/2 (Secretin family receptors)
Name
Explore in Pharos
Explore in Source
Activation of SMO
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Class B/2 (Secretin family receptors)
Gene Ontology Terms (73)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (107)
1 – 10 of 107
FAM189B
Tbio
Novelty: 0.21064304
p_int: 0.99995352
p_ni: 0.000046396
p_wrong: 8.4e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
PTCH1
Tbio
Novelty: 0.00077635
Score: 0.992
Data Source: Reactome,STRINGDB
GLI1
Tchem
Family: TF
Novelty: 0.00077281
Score: 0.99
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.99
Data Source: Reactome,STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.989
Data Source: STRINGDB
PTCH2
Tbio
Novelty: 0.00927849
Score: 0.986
Data Source: STRINGDB
GLI2
Tchem
Family: TF
Novelty: 0.00229126
Score: 0.986
Data Source: STRINGDB
GLI3
Tbio
Family: TF
Novelty: 0.00051217
Score: 0.984
Data Source: STRINGDB
SUFU
Tbio
Novelty: 0.00475249
Score: 0.982
Data Source: STRINGDB
DHH
Tbio
Novelty: 0.00329784
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.18

PubMed score by year
PubTator Score  441.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: