Tbio CCT7 T-complex protein 1 subunit eta

Protein Classes

PANTHER Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Eta

Protein Summary

Description

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q99832
• A8K7E6
• A8MWI8
• B7WNW9
• B7Z4T9
• B7Z4Z7
• O14871
• Q6FI26
• TCP-1-eta

Gene Name

• CCT7

Ensembl ID

• ENST00000258091
• ENSP00000258091
• ENSG00000135624
• ENST00000398422
• ENSP00000381456
• ENST00000539919
• ENSP00000437824
• ENST00000540468
• ENSP00000442058

Symbol

• CCTH
• NIP7-1
• CCTH
• CCTETA
• NIP7-1
• TCP1ETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
co-expressed gene	0.99
disease perturbation	0.97
hub protein	0.96

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.78   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 253   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.78   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (9)

Reactome (9)

Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

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1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	42 targets	R-HSA-6814122
Reactome	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Reactome	Folding of actin by CCT/TriC	10 targets	R-HSA-390450

Name	Explore in Pharos	Explore in Source
Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	42 targets	R-HSA-6814122
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Folding of actin by CCT/TriC	10 targets	R-HSA-390450

Gene Ontology Terms (17)

Functions (3)

Components (6)

Processes (8)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
unfolded protein binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
identical protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (494)

Explore Interacting Targets

1 – 10 of 494

• See Interactions on String-DB

DCAF12

Tbio

Novelty: 0.09567198

p_int: 0.999999698

p_ni: 3.02e-7

Score: 0.166

Data Source: BioPlex,STRINGDB

KLHDC8B

Tdark

Novelty: 0.21052632

p_int: 0.999997858

p_ni: 0.000001842

p_wrong: 3e-7

Score: 0.315

Data Source: BioPlex,STRINGDB

WDR25

Tdark

Novelty: 0.69230769

p_int: 0.999993765

p_ni: 0.000006235

Score: 0.221

Data Source: BioPlex,STRINGDB

WDR70

Tdark

Novelty: 1.2244898

p_int: 0.9999929

p_ni: 0.0000071

Score: 0.15

Data Source: BioPlex,STRINGDB

TUBD1

Tbio

Novelty: 0.05057515

p_int: 0.999989928

p_ni: 0.000006193

p_wrong: 0.000003878

Score: 0.232

Data Source: BioPlex,STRINGDB

CCT3

Tbio

Novelty: 0.00555442

p_int: 0.999973712

p_ni: 0.000026288

Score: 0.999

Data Source: BioPlex,STRINGDB

WDR46

Tdark

Novelty: 0.36421448

p_int: 0.999967528

p_ni: 0.000032472

Score: 0.274

Data Source: BioPlex,STRINGDB

DCAF13

Tbio

Novelty: 0.00828554

p_int: 0.999958662

p_ni: 0.000041338

Score: 0.591

Data Source: BioPlex,STRINGDB

WDR24

Tdark

Novelty: 1.44736842

p_int: 0.999943505

p_ni: 0.000048492

p_wrong: 0.000008003

Data Source: BioPlex

FBXW8

Tbio

Novelty: 0.08804388

p_int: 0.999943298

p_ni: 0.0000567

p_wrong: 3e-9

Score: 0.377

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  29.78

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PubTator Score  5.93

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Alternative splicing
ATP-binding
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Isopeptide bond
Methylation
Nucleotide-binding

GWAS Trait Find Similar Targets

age at voice drop
chronic kidney disease
cognitive function measurement
glomerular filtration rate
intelligence
self reported educational attainment
urinary metabolite measurement