Tbio CCT7 T-complex protein 1 subunit eta

Protein Summary

Description

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q99832
• A8K7E6
• A8MWI8
• B7WNW9
• B7Z4T9
• B7Z4Z7
• O14871
• Q6FI26
• TCP-1-eta

Gene Name

• CCT7

Ensembl ID

• ENST00000258091
• ENSP00000258091
• ENSG00000135624
• ENST00000398422
• ENSP00000381456
• ENST00000539919
• ENSP00000437824
• ENST00000540468
• ENSP00000442058

Symbol

• CCTH
• NIP7-1
• CCTH
• CCTETA
• NIP7-1
• TCP1ETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
co-expressed gene	0.99
disease perturbation	0.97
hub protein	0.96

Protein Classes

PANTHER Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Eta

DTO Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Eta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.27   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 253   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.27   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (494)

Explore Interacting Targets

1 – 10 of 494

• See Interactions on String-DB

DCAF12

Tbio

Novelty:  0.15472702

p_int:  0.999999698

p_ni:  3.02e-7

Score:  0.166

Data Source:  BioPlex,STRINGDB

KLHDC8B

Tbio

Novelty:  0.15409379

p_int:  0.999997858

p_ni:  0.000001842

p_wrong:  3e-7

Score:  0.315

Data Source:  BioPlex,STRINGDB

WDR25

Tdark

Novelty:  0.53632123

p_int:  0.999993765

p_ni:  0.000006235

Score:  0.221

Data Source:  BioPlex,STRINGDB

WDR70

Tdark

Novelty:  0.37521871

p_int:  0.9999929

p_ni:  0.0000071

Score:  0.15

Data Source:  BioPlex,STRINGDB

TUBD1

Tbio

Novelty:  0.03591414

p_int:  0.999989928

p_ni:  0.000006193

p_wrong:  0.000003878

Score:  0.232

Data Source:  BioPlex,STRINGDB

CCT3

Tbio

Novelty:  0.01642521

p_int:  0.999973712

p_ni:  0.000026288

Score:  0.999

Data Source:  BioPlex,STRINGDB

WDR46

Tbio

Novelty:  0.19307408

p_int:  0.999967528

p_ni:  0.000032472

Score:  0.274

Data Source:  BioPlex,STRINGDB

DCAF13

Tbio

Novelty:  0.02796363

p_int:  0.999958662

p_ni:  0.000041338

Score:  0.591

Data Source:  BioPlex,STRINGDB

WDR24

Tdark

Novelty:  0.48411996

p_int:  0.999943505

p_ni:  0.000048492

p_wrong:  0.000008003

Data Source:  BioPlex

FBXW8

Tbio

Novelty:  0.06697145

p_int:  0.999943298

p_ni:  0.0000567

p_wrong:  3e-9

Score:  0.377

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (9)

Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

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1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	42 targets	R-HSA-6814122
Reactome	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Reactome	Folding of actin by CCT/TriC	10 targets	R-HSA-390450

Name	Explore in Pharos	Explore in Source
Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	42 targets	R-HSA-6814122
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	33 targets	R-HSA-389958
Folding of actin by CCT/TriC	10 targets	R-HSA-390450

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (3)

Components (6)

Processes (8)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
unfolded protein binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
identical protein binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urinary metabolite measurement	EFO_0005116	1	1	2		69.5
intelligence	EFO_0004337	3	6	2	6	66.2
glomerular filtration rate	EFO_0005208	1	1	1		47.7
self reported educational attainment	EFO_0004784	2	2	2		46.9
puberty onset measurement	EFO_0005677	1	1	1		17.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urinary metabolite measurement	EFO_0005116	2		69.5
intelligence	EFO_0004337	2	6	66.2
glomerular filtration rate	EFO_0005208	1		47.7
self reported educational attainment	EFO_0004784	2		46.9
puberty onset measurement	EFO_0005677	1		17.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
ATP-binding
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Isopeptide bond
Methylation
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
age at voice drop
cognitive function measurement
glomerular filtration rate
intelligence
puberty onset measurement
self reported educational attainment
urinary metabolite measurement

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	chaperonin containing TCP1 subunit 7	VGNC:186	459323
Macaque	chaperonin containing TCP1 subunit 7		706157
Mouse	chaperonin containing Tcp1, subunit 7 (eta)	MGI:107184	12468
Rat	chaperonin containing TCP1 subunit 7	RGD:1306422	297406
Dog	T-complex protein 1 subunit eta		100856782

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chaperonin containing TCP1 subunit 7
Macaque	chaperonin containing TCP1 subunit 7
Mouse	chaperonin containing Tcp1, subunit 7 (eta)
Rat	chaperonin containing TCP1 subunit 7
Dog	T-complex protein 1 subunit eta

Publication Statistics

PubMed Score 47.27

PubMed score by year

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PubTator Score 5.93

PubTator score by year

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Related Publications

Text Mined References (24)

GeneRif Annotations (6)

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0 of 0

PMID	Year	Title