Tbio CCT7 T-complex protein 1 subunit eta

Protein Summary

Description

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q99832
• A8K7E6
• A8MWI8
• B7WNW9
• B7Z4T9
• B7Z4Z7
• O14871
• Q6FI26
• TCP-1-eta

Gene Name

• CCT7

Ensembl ID

• ENST00000258091
• ENSP00000258091
• ENSG00000135624
• ENST00000398422
• ENSP00000381456
• ENST00000539919
• ENSP00000437824
• ENST00000540468
• ENSP00000442058

Symbol

• CCTH
• NIP7-1
• CCTH
• CCTETA
• NIP7-1
• TCP1ETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
co-expressed gene	0.99
disease perturbation	0.97
hub protein	0.96

Protein Classes

PANTHER Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Eta

DTO Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Eta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.39   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 253   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.39   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0