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Tbio
CPNE1
Copine-1

Protein Summary
Description
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). Calcium-dependent membrane-binding proteins may re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352393
  • ENSP00000336945
  • ENSG00000214078
  • ENST00000397443
  • ENSP00000380585

Symbol
  • CPN1
  • CPN1
  • COPN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor
0.78
transcription factor binding site profile
0.6
disease perturbation
0.56
cell line
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.45   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.45   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
87.5
intelligence
1
1
0
5.6
61.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
87.5
intelligence
0
5.6
61.3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2386621
266692
Dog
copine 1
VGNC:39560
477213
Horse
copine 1
VGNC:16823
100054882
Cow
copine 1
VGNC:27658
615677
Pig
copine 1
100233174
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
copine 1
Horse
copine 1
Cow
copine 1
Pig
copine 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99829-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Gene Ontology Terms (30)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (95)
1 – 10 of 95
KLK5
Tchem
Family: Enzyme
Novelty: 0.00835407
p_int: 0.929106251
p_ni: 0.070893748
p_wrong: 1e-9
Score: 0.345
Data Source: BioPlex,STRINGDB
STOM
Tbio
Novelty: 0.00459891
Score: 0.909
Data Source: STRINGDB
MAGT1
Tbio
Novelty: 0.02144318
Score: 0.906
Data Source: STRINGDB
VNN1
Tchem
Family: Enzyme
Novelty: 0.0144646
Score: 0.906
Data Source: STRINGDB
DNAJC13
Tbio
Novelty: 0.03251995
Score: 0.905
Data Source: STRINGDB
CPNE3
Tbio
Novelty: 0.06125038
Score: 0.904
Data Source: STRINGDB
BST2
Tbio
Novelty: 0.00254359
Score: 0.903
Data Source: STRINGDB
ACPP
Tchem
Family: Enzyme
Novelty: 0.00364265
Score: 0.903
Data Source: STRINGDB
ATP8A1
Tbio
Family: Transporter
Novelty: 0.02003643
Score: 0.903
Data Source: STRINGDB
RAB37
Tbio
Family: Enzyme
Novelty: 0.07133253
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.45

PubMed score by year
PubTator Score  15.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer