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Tchem
EPAS1
Endothelial PAS domain-containing protein 1

Protein Summary
Description
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity). This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263734
  • ENSP00000263734
  • ENSG00000116016

Symbol
  • BHLHE73
  • HIF2A
  • MOP2
  • PASD2
  • HLF
  • MOP2
  • ECYT4
  • HIF2A
  • PASD2
  • bHLHe73
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
0.96
protein domain
0.92
biological process
0.91
gene perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.98   (req: < 5)
Gene RIFs: 404   (req: <= 3)
Antibodies: 630   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.98   (req: >= 5)
Gene RIFs: 404   (req: > 3)
Antibodies: 630   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.2
94.5
hemoglobin measurement
2
2
2
40.6
birth weight
1
1
1
37.5
hematocrit
1
1
1
22.3
electrocardiography
1
1
10
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
94.5
hemoglobin measurement
2
40.6
birth weight
1
37.5
hematocrit
1
22.3
electrocardiography
10
21.6
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (93)
Cellular response to hypoxia (R-HSA-1234174)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Developmental Biology
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Developmental Biology
Metabolism of proteins
Gene Ontology Terms (35)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Genetic Interaction (IGI)
MGI
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (213)
1 – 10 of 213
EGLN1
Tclin
Novelty: 0.00236525
Score: 0.997
Data Source: Reactome,STRINGDB
ARNT
Tbio
Family: TF
Novelty: 0.00183071
Score: 0.997
Data Source: Reactome,STRINGDB
EGLN2
Tclin
Novelty: 0.00570785
Score: 0.994
Data Source: Reactome,STRINGDB
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
Score: 0.994
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.988
Data Source: Reactome,STRINGDB
ELOC
Tbio
Novelty: 0.00964847
Score: 0.986
Data Source: Reactome,STRINGDB
EGLN3
Tclin
Novelty: 0.00643992
Score: 0.983
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.98
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.979
Data Source: Reactome,STRINGDB
EPO
Tbio
Novelty: 0.00013701
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  316.98

PubMed score by year
PubTator Score  770.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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