PRRX2
Paired mesoderm homeobox protein 2
Protein Summary
May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
- ENST00000372469
- ENSP00000361547
- ENSG00000167157
- PMX2
- PRX2
- PMX2
- PRX2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.84 | ||
PubMedID | 0.66 | ||
tissue sample | 0.61 | ||
transcription factor | 0.59 | ||
virus perturbation | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.5 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.5 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0