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Tclin
SLC29A1
Equilibrative nucleoside transporter 1

Protein Summary
Description
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371708
  • ENSP00000360773
  • ENSG00000112759
  • ENST00000371713
  • ENSP00000360778
  • ENST00000371724
  • ENSP00000360789
  • ENST00000371755
  • ENSP00000360820
  • ENST00000393844
  • ENSP00000377427
  • ENST00000427851
  • ENSP00000392668

Symbol
  • ENT1
  • ENT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
kinase perturbation
0.88
gene perturbation
0.87
transcription factor perturbation
0.8
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 608.47   (req: < 5)
Gene RIFs: 125   (req: <= 3)
Antibodies: 511   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 608.47   (req: >= 5)
Gene RIFs: 125   (req: > 3)
Antibodies: 511   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 187
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (187)
CHEMBL92870
Rendered image for CHEMBL92870
dilazep
Rendered image for dilazep
draflazine
Rendered image for draflazine
KF24345
Rendered image for KF24345
NBTGR
Rendered image for NBTGR
CHEMBL571939
Rendered image for CHEMBL571939
CHEMBL569223
Rendered image for CHEMBL569223
CHEMBL569224
Rendered image for CHEMBL569224
Protein-Protein Interactions (100)
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.995698558
p_ni:  0.004301258
p_wrong:  1.85e-7
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.984009469
p_ni:  0.015990057
p_wrong:  4.74e-7
Data Source:  BioPlex
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.982276194
p_ni:  0.016909072
p_wrong:  0.000814734
Score:  0.353
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.976753176
p_ni:  0.023246664
p_wrong:  1.6e-7
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.962212817
p_ni:  0.037786603
p_wrong:  5.8e-7
Score:  0.48
Data Source:  BioPlex,STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.94837061
p_ni:  0.050880034
p_wrong:  0.000749356
Score:  0.151
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.947894509
p_ni:  0.052077028
p_wrong:  0.000028463
Score:  0.17
Data Source:  BioPlex,STRINGDB
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.9392908
p_ni:  0.060670459
p_wrong:  0.000038741
Score:  0.151
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.93877213
p_ni:  0.061227858
p_wrong:  1.1e-8
Data Source:  BioPlex
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.938770919
p_ni:  0.061229007
p_wrong:  7.4e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
5
1.2
95.6
mean reticulocyte volume
1
2
2
75.3
mean corpuscular volume
1
2
2
73.9
diastolic blood pressure
1
1
1
61.4
monocyte percentage of leukocytes
2
1
2
60.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.2
95.6
mean reticulocyte volume
2
75.3
mean corpuscular volume
2
73.9
diastolic blood pressure
1
61.4
monocyte percentage of leukocytes
2
60.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 29 member 1
VGNC:7924
462728
Macaque
solute carrier family 29 member 1 (Augustine blood group)
703031
Mouse
MGI:1927073
63959
Rat
RGD:61899
63997
Horse
solute carrier family 29 member 1
VGNC:53563
100055498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 29 member 1
Macaque
solute carrier family 29 member 1 (Augustine blood group)
Mouse
Rat
Horse
solute carrier family 29 member 1
Publication Statistics
PubMed Score 608.47
PubMed score by year
PubTator Score 373.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title