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Tbio
NKX3-1
Homeobox protein Nkx-3.1

Protein Summary
Description
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380871
  • ENSP00000370253
  • ENSG00000167034
  • ENST00000523261
  • ENSP00000429729

Symbol
  • NKX3.1
  • NKX3A
  • NKX3
  • BAPX2
  • NKX3A
  • NKX3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
histone modification site profile
0.78
virus perturbation
0.76
microRNA
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.65   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 626   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.65   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 626   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
0
1.2
94
BMI-adjusted waist-hip ratio
8
7
15
93.7
waist-hip ratio
4
5
7
92.5
prostate specific antigen measurement
2
2
2
81.9
BMI-adjusted waist circumference
5
3
6
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
94
BMI-adjusted waist-hip ratio
15
93.7
waist-hip ratio
7
92.5
prostate specific antigen measurement
2
81.9
BMI-adjusted waist circumference
6
81.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NK3 homeobox 1
VGNC:14633
743612
Macaque
NK3 homeobox 1
710591
Mouse
MGI:97352
18095
Rat
RGD:1305369
305999
Horse
NK3 homeobox 1
VGNC:50729
100058172
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NK3 homeobox 1
Macaque
NK3 homeobox 1
Mouse
Rat
Horse
NK3 homeobox 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99801-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (61)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (90)
1 – 10 of 90
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.814162531
p_wrong:  0.185837469
Score:  0.202
Data Source:  BioPlex,STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.893
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.887
Data Source:  STRINGDB
TMPRSS2
Tchem
Family:  Enzyme
Novelty:  0.00117884
Score:  0.856
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.811
Data Source:  STRINGDB
AKT3
Tchem
Family:  Kinase
Novelty:  0.00308931
Score:  0.811
Data Source:  STRINGDB
SPDEF
Tbio
Family:  TF
Novelty:  0.00618802
Score:  0.8
Data Source:  STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.795
Data Source:  STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.793
Data Source:  STRINGDB
TOPORS
Tbio
Family:  Enzyme
Novelty:  0.03910082
Score:  0.726
Data Source:  STRINGDB
Publication Statistics
PubMed Score  219.65

PubMed score by year
PubTator Score  274.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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