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Tbio
ACO2
Aconitate hydratase, mitochondrial

Protein Summary
Description
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216254
  • ENSP00000216254
  • ENSG00000100412

Symbol
  • ICRD
  • OCA8
  • OPA9
  • ACONM
  • HEL-S-284
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.98
protein domain
0.97
interacting protein
0.9
transcription factor binding site profile
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.88   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 454   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.88   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
49.2
body height
1
1
1
16.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
49.2
body height
1
16.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aconitase 2
VGNC:5224
104003784
Macaque
aconitase 2
707441
Mouse
MGI:87880
11429
Rat
RGD:621360
79250
Dog
aconitase 2
VGNC:37514
474487
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aconitase 2
Macaque
aconitase 2
Mouse
Rat
Dog
aconitase 2
Pathways (21)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Mitochondrial protein import
Reactome
Protein localization
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Mitochondrial protein import
Protein localization
Pyruvate metabolism and Citric Acid (TCA) cycle
Protein-Protein Interactions (283)
1 – 10 of 283
IDH3A
Tbio
Family: Enzyme
Novelty: 0.02027198
Score: 0.998
Data Source: STRINGDB
IDH3G
Tbio
Family: Enzyme
Novelty: 0.04861242
Score: 0.998
Data Source: STRINGDB
CS
Tbio
Family: Enzyme
Novelty: 0.00154214
Score: 0.995
Data Source: STRINGDB
IDH3B
Tbio
Family: Enzyme
Novelty: 0.04326765
Score: 0.994
Data Source: STRINGDB
FXN
Tbio
Novelty: 0.00084064
Score: 0.991
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
Score: 0.99
Data Source: STRINGDB
IDH2
Tclin
Family: Enzyme
Novelty: 0.00131782
Score: 0.981
Data Source: STRINGDB
IDH1
Tclin
Family: Enzyme
Novelty: 0.0004831
Score: 0.979
Data Source: STRINGDB
SLC25A12
Tbio
Family: Transporter
Novelty: 0.01205065
Score: 0.972
Data Source: STRINGDB
ACLY
Tclin
Family: Enzyme
Novelty: 0.00114812
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  331.88

PubMed score by year
PubTator Score  144.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer