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Tbio
GPA33
Cell surface A33 antigen

Protein Summary
Description
May play a role in cell-cell recognition and signaling. The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367868
  • ENSP00000356842
  • ENSG00000143167

Symbol
  • A33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
cell type or tissue
0.7
transcription factor perturbation
0.68
PubMedID
0.65
interacting protein
0.61


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.62   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.62   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycoprotein A33
VGNC:52950
748242
Mouse
MGI:1891703
59290
Rat
RGD:1306711
360873
Dog
glycoprotein A33
VGNC:53485
611598
Horse
glycoprotein A33
VGNC:50841
100056610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycoprotein A33
Mouse
Rat
Dog
glycoprotein A33
Horse
glycoprotein A33
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99795-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (40)
1 – 10 of 40
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
Score:  0.905
Data Source:  STRINGDB
PKP3
Tbio
Novelty:  0.0269462
Score:  0.844
Data Source:  STRINGDB
PPL
Tbio
Novelty:  0.00684645
Score:  0.837
Data Source:  STRINGDB
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
Score:  0.804
Data Source:  STRINGDB
HAGH
Tbio
Family:  Enzyme
Novelty:  0.00689153
Score:  0.802
Data Source:  STRINGDB
HSF4
Tbio
Family:  TF
Novelty:  0.01736563
Score:  0.716
Data Source:  STRINGDB
CYP27A1
Tchem
Family:  Enzyme
Novelty:  0.00071796
Score:  0.711
Data Source:  STRINGDB
F11R
Tbio
Novelty:  0.00182817
Score:  0.692
Data Source:  STRINGDB
HAS1
Tbio
Family:  Enzyme
Novelty:  0.02014779
Score:  0.669
Data Source:  STRINGDB
MAMLD1
Tbio
Novelty:  0.01681081
Score:  0.64
Data Source:  STRINGDB
Publication Statistics
PubMed Score  128.62

PubMed score by year
PubTator Score  97.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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