Tchem CMKLR1 Chemokine-like receptor 1

Protein Summary

Description

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Uniprot Accession IDs

• Q99788
• A8K6Y5
• O75748
• Q3KP37
• Q5U0H0
• Q99789

Gene Name

• CMKLR1

Ensembl ID

• ENST00000312143
• ENSP00000311733
• ENSG00000174600
• ENST00000412676
• ENSP00000401293
• ENST00000550402
• ENSP00000449716
• ENST00000552995
• ENSP00000447579

Symbol

• CHEMR23
• DEZ
• DEZ
• RVER1
• ChemR23
• CHEMERINR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.87
biological process	0.64
tissue sample	0.61
cell line	0.6
PubMedID	0.6

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Chemokine-like Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemerin Receptor / Chemokine-like Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.75   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 537   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.75   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 537   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0