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Tbio
OLFM1
Noelin

Protein Summary
Description
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252854
  • ENSP00000252854
  • ENSG00000130558
  • ENST00000277415
  • ENSP00000277415
  • ENST00000371793
  • ENSP00000360858
  • ENST00000371796
  • ENSP00000360861
  • ENST00000392991
  • ENSP00000376717

Symbol
  • NOE1
  • NOEL1
  • AMY
  • NOE1
  • OlfA
  • NOELIN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor perturbation
0.91
kinase perturbation
0.88
PubMedID
0.88
small molecule perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.06   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 373   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.06   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 373   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
OLFM2
Tbio
Novelty:  0.06929963
p_int:  0.999977962
p_ni:  0.000022038
Score:  0.603
Data Source:  BioPlex,STRINGDB
MANEA
Tbio
Family:  Enzyme
Novelty:  0.03693244
p_int:  0.999961139
p_ni:  0.000038861
Score:  0.192
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999568257
p_ni:  0.000431743
Score:  0.234
Data Source:  BioPlex,STRINGDB
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.997042251
p_ni:  0.000031505
p_wrong:  0.002926243
Score:  0.165
Data Source:  BioPlex,STRINGDB
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.965382947
p_ni:  0.034617053
Score:  0.183
Data Source:  BioPlex,STRINGDB
ASPH
Tbio
Family:  Enzyme
Novelty:  0.00291455
p_int:  0.958947851
p_ni:  0.041052149
Score:  0.211
Data Source:  BioPlex,STRINGDB
PCOLCE2
Tbio
Family:  Enzyme
Novelty:  0.13084379
p_int:  0.854301869
p_ni:  0.003652136
p_wrong:  0.142045995
Score:  0.336
Data Source:  BioPlex,STRINGDB
EHMT1
Tchem
Family:  Epigenetic
Novelty:  0.00821799
Score:  0.809
Data Source:  STRINGDB
CACNA1B
Tclin
Family:  IC
Novelty:  0.00319692
Score:  0.801
Data Source:  STRINGDB
VAV2
Tbio
Novelty:  0.01062502
Score:  0.657
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
AgBase
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
49.5
mathematical ability
2
1
2
42.3
smoking behavior
1
1
1
39.6
body mass index
1
1
1
29
smoking initiation
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
49.5
mathematical ability
2
42.3
smoking behavior
1
39.6
body mass index
1
29
smoking initiation
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1860437
56177
Rat
RGD:620320
93667
Horse
olfactomedin 1
VGNC:21021
100066407
Cow
olfactomedin 1
VGNC:32417
507002
Platypus
olfactomedin 1
100074788
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
olfactomedin 1
Cow
olfactomedin 1
Platypus
olfactomedin 1
Publication Statistics
PubMed Score 49.06
PubMed score by year
PubTator Score 13.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title