Protein Summary
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000252854
- ENSP00000252854
- ENSG00000130558
- ENST00000277415
- ENSP00000277415
- ENST00000371793
- ENSP00000360858
- ENST00000371796
- ENSP00000360861
- ENST00000392991
- ENSP00000376717
- NOE1
- NOEL1
- AMY
- NOE1
- OlfA
- NOELIN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.98 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.88 | ||
PubMedID | 0.88 | ||
small molecule perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.3 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 373 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.3 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 373 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0