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Tchem
MAP3K3
Mitogen-activated protein kinase kinase kinase 3

Protein Summary
Description
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361357
  • ENSP00000354927
  • ENSG00000198909
  • ENST00000361733
  • ENSP00000354485
  • ENST00000579585
  • ENSP00000461988

Symbol
  • MAPKKK3
  • MEKK3
  • MEKK3
  • MAPKKK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
drug perturbation
0.99
molecular function
0.99
small molecule
0.95


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.93   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.93   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL603469
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
2
2
89.7
body mass index
2
1
2
85.3
body height
5
4
6
85
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
89.7
body mass index
2
85.3
body height
6
85
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 3
VGNC:9367
468286
Macaque
mitogen-activated protein kinase kinase kinase 3
717866
Mouse
MGI:1346874
26406
Rat
RGD:1304575
303604
Dog
mitogen-activated protein kinase kinase kinase 3
VGNC:42973
480481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 3
Macaque
mitogen-activated protein kinase kinase kinase 3
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 3
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99759-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Signaling by Interleukins
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (117)
1 – 10 of 117
MAP2K5
Tchem
Family: Kinase
Novelty: 0.00587774
p_int: 0.999953191
p_ni: 0.000046808
p_wrong: 1e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
CCM2
Tbio
Novelty: 0.00785958
Score: 0.999
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.977
Data Source: Reactome,STRINGDB
MAP2K4
Tchem
Family: Kinase
Novelty: 0.00252847
Score: 0.961
Data Source: STRINGDB
CHUK
Tchem
Family: Kinase
Novelty: 0.00151532
Score: 0.961
Data Source: STRINGDB
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
Score: 0.96
Data Source: STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.956
Data Source: STRINGDB
MAP2K7
Tchem
Family: Kinase
Novelty: 0.00916401
Score: 0.954
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.954
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  69.93

PubMed score by year
PubTator Score  49.51

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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