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Tbio
ABCA3
ATP-binding cassette sub-family A member 3

Protein Summary
Description
Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301732
  • ENSP00000301732
  • ENSG00000167972
  • ENST00000567910
  • ENSP00000454397

Symbol
  • ABC3
  • ABC3
  • ABC-C
  • SMDP3
  • LBM180
  • EST111653
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.91
disease perturbation
0.87
protein domain
0.85
transcription factor
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
16.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
16.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily A member 3
VGNC:5662
453833
Macaque
ATP binding cassette subfamily A member 3
696496
Mouse
MGI:1351617
27410
Dog
ATP binding cassette subfamily A member 3
VGNC:37426
479879
Horse
ATP binding cassette subfamily A member 3
VGNC:14902
100068313
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily A member 3
Macaque
ATP binding cassette subfamily A member 3
Mouse
Dog
ATP binding cassette subfamily A member 3
Horse
ATP binding cassette subfamily A member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99758-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)
Reactome
Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)
Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)
Protein-Protein Interactions (78)
1 – 10 of 78
ASIC4
Tbio
Family: IC
Novelty: 0.02912816
p_int: 0.996057836
p_ni: 0.003942164
Data Source: BioPlex
MCOLN3
Tchem
Family: IC
Novelty: 0.03209262
p_int: 0.995789378
p_ni: 0.004210622
Score: 0.158
Data Source: BioPlex,STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
p_int: 0.978053603
p_ni: 0.021946397
Data Source: BioPlex
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.52190272
p_int: 0.962779019
p_ni: 0.037220981
Data Source: BioPlex
HTR3A
Tclin
Family: IC
Novelty: 0.00217443
p_int: 0.962641289
p_ni: 0.037358711
Data Source: BioPlex
CHRND
Tclin
Family: IC
Novelty: 0.0441685
p_int: 0.96133918
p_ni: 0.03866082
Data Source: BioPlex
IL17RC
Tclin
Novelty: 0.01844832
p_int: 0.959472326
p_ni: 0.040527674
Data Source: BioPlex
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.952950149
p_ni: 0.047049851
Score: 0.153
Data Source: BioPlex,STRINGDB
TMEM9B
Tdark
Novelty: 0.56628366
p_int: 0.93824916
p_ni: 0.06175084
Data Source: BioPlex
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.933656015
p_ni: 0.066343985
Data Source: BioPlex
Publication Statistics
PubMed Score  285.00

PubMed score by year
PubTator Score  175.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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