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Tbio
TXN2
Thioredoxin, mitochondrial

Protein Summary
Description
Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216185
  • ENSP00000216185
  • ENSG00000100348
  • ENST00000403313
  • ENSP00000385393

Symbol
  • TRX2
  • TXN
  • MTRX
  • TRX2
  • MT-TRX
  • COXPD29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.97
histone modification site profile
0.92
transcription factor perturbation
0.88
transcription factor binding site profile
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.64   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.64   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1929468
56551
Rat
RGD:71040
79462
Dog
thioredoxin 2
VGNC:48009
474519
Horse
thioredoxin 2
VGNC:24675
100069490
Cow
thioredoxin 2
VGNC:36533
281557
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
thioredoxin 2
Horse
thioredoxin 2
Cow
thioredoxin 2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Degradation of cysteine and homocysteine
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Degradation of cysteine and homocysteine
Detoxification of Reactive Oxygen Species
Metabolism
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (115)
1 – 10 of 115
TXNIP
Tbio
Novelty: 0.00216952
p_int: 0.925425718
p_ni: 0.074574282
Score: 0.947
Data Source: BioPlex,STRINGDB
PRDX3
Tbio
Family: Enzyme
Novelty: 0.00340119
Score: 0.985
Data Source: Reactome,STRINGDB
TXNRD2
Tbio
Family: Enzyme
Novelty: 0.002052
Score: 0.982
Data Source: Reactome,STRINGDB
TXN
Tchem
Novelty: 0.00048949
Score: 0.93
Data Source: STRINGDB
MPST
Tchem
Family: Enzyme
Novelty: 0.00611672
Score: 0.908
Data Source: Reactome,STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.858
Data Source: STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00299018
Score: 0.855
Data Source: STRINGDB
GPX4
Tbio
Family: Enzyme
Novelty: 0.00188213
Score: 0.829
Data Source: STRINGDB
GSR
Tclin
Family: Enzyme
Novelty: 0.00040107
Score: 0.824
Data Source: STRINGDB
PTBP3
Tbio
Novelty: 0.02001829
Score: 0.82
Data Source: STRINGDB
Publication Statistics
PubMed Score  185.64

PubMed score by year
PubTator Score  81.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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