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Tbio
PIP5K1A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Protein Summary
Description
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin poly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349792
  • ENSP00000271663
  • ENSG00000143398
  • ENST00000368888
  • ENSP00000357883
  • ENST00000368890
  • ENSP00000357885
  • ENST00000441902
  • ENSP00000415648
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
transcription factor perturbation
0.94
disease perturbation
0.83
transcription factor binding site profile
0.83
biological process
0.75


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.59   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.59   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
VGNC:11766
457288
Mouse
MGI:107929
18720
Rat
RGD:1306127
365865
Dog
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
475846
Cow
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
100125224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Mouse
Rat
Dog
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Cow
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99755-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (33)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Negative regulation of the PI3K/AKT network
Reactome
PI Metabolism
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
Metabolism
Metabolism of lipids
Negative regulation of the PI3K/AKT network
PI Metabolism
Gene Ontology Terms (30)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (154)
1 – 10 of 154
PIP5K1C
Tchem
Family: Kinase
Novelty: 0.0323077
p_int: 0.999999112
p_ni: 4e-9
p_wrong: 8.85e-7
Score: 0.963
Data Source: BioPlex,STRINGDB
NRXN3
Tbio
Novelty: 0.00999084
p_int: 0.999995463
p_ni: 0.000004508
p_wrong: 3e-8
Score: 0.211
Data Source: BioPlex,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.06786314
p_int: 0.999995006
p_ni: 0.000004993
p_wrong: 1e-9
Data Source: BioPlex
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999969685
p_ni: 0.000030315
Score: 0.93
Data Source: BioPlex,STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
p_int: 0.99995138
p_ni: 0.00004862
Score: 0.151
Data Source: BioPlex,STRINGDB
IMPDH1
Tclin
Family: Enzyme
Novelty: 0.00758575
p_int: 0.999713546
p_ni: 0.000286454
Score: 0.333
Data Source: BioPlex,STRINGDB
TRIM41
Tbio
Family: Enzyme
Novelty: 0.17238173
p_int: 0.999648754
p_ni: 0.000351245
p_wrong: 1e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.999132565
p_ni: 0.000867428
p_wrong: 8e-9
Data Source: BioPlex
ZNF653
Tbio
Family: TF
Novelty: 1.467544
p_int: 0.998481704
p_ni: 0.001518295
p_wrong: 1e-9
Data Source: BioPlex
CCDC97
Tdark
Novelty: 2.36351796
p_int: 0.998147831
p_ni: 0.001852169
Data Source: BioPlex
Publication Statistics
PubMed Score  17.59

PubMed score by year
PubTator Score  16.61

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer