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Tbio
NPAS2
Neuronal PAS domain-containing protein 2

Protein Summary
Description
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335681
  • ENSP00000338283
  • ENSG00000170485

Symbol
  • BHLHE9
  • MOP4
  • PASD4
  • MOP4
  • PASD4
  • bHLHe9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
PubMedID
0.85
co-expressed gene
0.82
biological process
0.76
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.62   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.62   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
3
3
58.2
serum gamma-glutamyl transferase measurement
1
1
1
57.8
intraocular pressure measurement
3
3
3
52.3
BMI-adjusted hip circumference
1
3
3
51.7
reticulocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
58.2
serum gamma-glutamyl transferase measurement
1
57.8
intraocular pressure measurement
3
52.3
BMI-adjusted hip circumference
3
51.7
reticulocyte count
1
44.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neuronal PAS domain protein 2
710480
Mouse
MGI:109232
18143
Rat
RGD:1309681
316351
Dog
neuronal PAS domain protein 2
VGNC:43909
474552
Horse
neuronal PAS domain protein 2
VGNC:20828
100059275
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neuronal PAS domain protein 2
Mouse
Rat
Dog
neuronal PAS domain protein 2
Horse
neuronal PAS domain protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99743-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (49)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Metabolism
Metabolism of lipids
PPARA activates gene expression
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (105)
1 – 10 of 105
CIPC
Tdark
Novelty:  0.02263148
p_int:  0.999999742
p_ni:  1e-9
p_wrong:  2.57e-7
Score:  0.531
Data Source:  BioPlex,STRINGDB
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.999476204
p_ni:  2.7e-8
p_wrong:  0.00052377
Score:  0.881
Data Source:  BioPlex,STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
p_int:  0.998849063
p_ni:  5.94e-7
p_wrong:  0.001150342
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
FHL2
Tbio
Novelty:  0.00501273
p_int:  0.966104518
p_ni:  0.033895482
Data Source:  BioPlex
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.900645307
p_ni:  0.099209733
p_wrong:  0.000144961
Data Source:  BioPlex
PALD1
Tbio
Novelty:  0.0248863
p_int:  0.767948412
p_ni:  0.232051588
Data Source:  BioPlex
CRY2
Tbio
Novelty:  0.00156961
Score:  0.997
Data Source:  Reactome,STRINGDB
CRY1
Tchem
Novelty:  0.00116593
Score:  0.996
Data Source:  Reactome,STRINGDB
BHLHE41
Tbio
Family:  TF
Novelty:  0.01015053
Score:  0.993
Data Source:  STRINGDB
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
Score:  0.984
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  144.62

PubMed score by year
PubTator Score  58.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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