Tbio CDC6 Cell division control protein 6 homolog

Protein Summary

Description

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99741
• Q8TB30

Gene Name

• CDC6

Ensembl ID

• ENST00000209728
• ENSP00000209728
• ENSG00000094804
• ENST00000647931
• ENSP00000497975
• ENST00000649662
• ENSP00000497345

Symbol

• CDC18L
• CDC18L
• HsCDC6
• MGORS5
• HsCDC18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
transcription factor perturbation	0.88
biological process	0.86
molecular function	0.86
hub protein	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 532.87   (req: < 5)

Gene RIFs: 94   (req: <= 3)

Antibodies: 711   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 532.87   (req: >= 5)

Gene RIFs: 94   (req: > 3)

Antibodies: 711   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0