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Tbio
CDC6
Cell division control protein 6 homolog

Protein Summary
Description
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209728
  • ENSP00000209728
  • ENSG00000094804
  • ENST00000647931
  • ENSP00000497975
  • ENST00000649662
  • ENSP00000497345

Symbol
  • CDC18L
  • CDC18L
  • HsCDC6
  • MGORS5
  • HsCDC18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
transcription factor perturbation
0.88
biological process
0.86
molecular function
0.86
hub protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 471.21   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 711   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 471.21   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 711   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Reactome
CDK-mediated phosphorylation and removal of Cdc6
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
CDK-mediated phosphorylation and removal of Cdc6
Gene Ontology Terms (29)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (497)
1 – 10 of 497
CCNF
Tbio
Novelty: 0.01288697
p_int: 0.999993886
p_ni: 0.000004406
p_wrong: 0.000001707
Score: 0.864
Data Source: BioPlex,STRINGDB
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.999480976
p_ni: 0.000519024
Data Source: BioPlex
ISLR
Tbio
Novelty: 0.02936208
p_int: 0.999465872
p_ni: 0.000534128
Data Source: BioPlex
IL20RA
Tbio
Novelty: 0.02416816
p_int: 0.993525629
p_ni: 0.006474369
p_wrong: 2e-9
Data Source: BioPlex
TNFRSF1A
Tchem
Novelty: 0.00037847
p_int: 0.993466408
p_ni: 0.006533583
p_wrong: 9e-9
Data Source: BioPlex
FAM131B
Tdark
Novelty: 0.3424123
p_int: 0.992070232
p_ni: 0.007929767
p_wrong: 1e-9
Data Source: BioPlex
PROZ
Tbio
Family: Enzyme
Novelty: 0.05629679
p_int: 0.990579956
p_ni: 0.009420032
p_wrong: 1.2e-8
Data Source: BioPlex
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.983170843
p_ni: 0.016789325
p_wrong: 0.000039832
Data Source: BioPlex
TIGIT
Tbio
Novelty: 0.0064542
p_int: 0.957965549
p_ni: 0.042026228
p_wrong: 0.000008223
Data Source: BioPlex
PCDHB11
Tdark
Novelty: 0.80480462
p_int: 0.948646701
p_ni: 0.05135329
p_wrong: 9e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  471.21

PubMed score by year
PubTator Score  179.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer