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Tbio
CCL19
C-C motif chemokine 19

Protein Summary
Description
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311925
  • ENSP00000308815
  • ENSG00000172724

Symbol
  • ELC
  • MIP3B
  • SCYA19
  • ELC
  • CKb11
  • MIP3B
  • MIP-3b
  • SCYA19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.76
biological term
0.67
tissue sample
0.58
disease
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.08   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.08   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (353)
KDM4A
Tchem
Family:  Epigenetic
Novelty:  0.00643043
p_int:  0.999999406
p_ni:  5.77e-7
p_wrong:  1.7e-8
Data Source:  BioPlex
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.995535058
p_ni:  0.004464942
Data Source:  BioPlex
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.995471987
p_ni:  0.004528013
Data Source:  BioPlex
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
p_int:  0.992184999
p_ni:  0.007815001
Data Source:  BioPlex
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.937309052
p_ni:  0.061797841
p_wrong:  0.000893108
Data Source:  BioPlex
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.885038044
p_ni:  0.072125046
p_wrong:  0.042836911
Data Source:  BioPlex
FRAS1
Tbio
Novelty:  0.02114063
p_int:  0.871456059
p_ni:  0.128543941
Data Source:  BioPlex
RB1
Tchem
Novelty:  0.00063798
p_int:  0.856132083
p_ni:  0.142556872
p_wrong:  0.001311045
Data Source:  BioPlex
SUSD1
Tdark
Novelty:  0.54249826
p_int:  0.834779776
p_ni:  0.146375288
p_wrong:  0.018844936
Data Source:  BioPlex
ANKRD46
Tbio
Novelty:  0.06546845
p_int:  0.821453255
p_ni:  0.178546499
p_wrong:  2.46e-7
Data Source:  BioPlex
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (18)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (60)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
1
1
80.5
7
3
2
1.1
77
testosterone measurement
1
1
1
29
body height
1
1
1
13.1
self reported educational attainment
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
80.5
2
1.1
77
testosterone measurement
1
29
body height
1
13.1
self reported educational attainment
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 19
VGNC:4650
473220
Macaque
C-C motif chemokine ligand 19
574386
Mouse
MGI:1346316
24047
Rat
RGD:1310336
362506
Dog
C-C motif chemokine ligand 19
VGNC:38883
448793
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 19
Macaque
C-C motif chemokine ligand 19
Mouse
Rat
Dog
C-C motif chemokine ligand 19
Publication Statistics
PubMed Score 554.08
PubMed score by year
PubTator Score 241.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title