Tbio CCL19 C-C motif chemokine 19

Protein Summary

Description

May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q99731
• O00697
• O00736

Gene Name

• CCL19

Ensembl ID

• ENST00000311925
• ENSP00000308815
• ENSG00000172724

Symbol

• ELC
• MIP3B
• SCYA19
• ELC
• CKb11
• MIP3B
• MIP-3b
• SCYA19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
PubMedID	0.76
biological term	0.67
tissue sample	0.58
disease	0.54

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 19

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 19

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 758.36   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 438   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 758.36   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0