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Tbio
HNRNPAB
Heterogeneous nuclear ribonucleoprotein A/B

Protein Summary
Description
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355836
  • ENSP00000348093
  • ENSG00000197451
  • ENST00000358344
  • ENSP00000351108
  • ENST00000504898
  • ENSP00000425031
  • ENST00000506259
  • ENSP00000427465

Symbol
  • ABBP1
  • HNRPAB
  • ABBP1
  • HNRPAB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
kinase perturbation
0.99
transcription factor perturbation
0.99
protein complex
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Protein-Protein Interactions (192)
1 – 10 of 192
PTBP1
Tbio
Novelty:  0.00184728
Score:  0.943
Data Source:  STRINGDB
HNRNPA2B1
Tbio
Novelty:  0.00404935
Score:  0.932
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.929
Data Source:  STRINGDB
UBE2G2
Tbio
Novelty:  0.04298958
Score:  0.888
Data Source:  STRINGDB
HNRNPA3
Tbio
Novelty:  0.03214786
Score:  0.873
Data Source:  STRINGDB
HNRNPD
Tbio
Novelty:  0.00538829
Score:  0.872
Data Source:  STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.853
Data Source:  STRINGDB
MRPS7
Tbio
Novelty:  0.00153134
Score:  0.843
Data Source:  STRINGDB
ALYREF
Tbio
Novelty:  0.00523802
Score:  0.827
Data Source:  STRINGDB
APOBEC1
Tbio
Novelty:  0.00622042
Score:  0.819
Data Source:  STRINGDB
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
83.9
reticulocyte measurement
2
1
2
73.7
reticulocyte count
1
1
1
70
platelet count
2
2
2
58.2
mean platelet volume
2
1
2
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
83.9
reticulocyte measurement
2
73.7
reticulocyte count
1
70
platelet count
2
58.2
mean platelet volume
2
36.9
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein A/B
VGNC:4037
462319
Macaque
heterogeneous nuclear ribonucleoprotein A/B
702509
Mouse
MGI:1330294
15384
Rat
RGD:69255
83498
Dog
heterogeneous nuclear ribonucleoprotein A/B [Source:HGNC Symbol;Acc:HGNC:5034]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein A/B
Macaque
heterogeneous nuclear ribonucleoprotein A/B
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein A/B [Source:HGNC Symbol;Acc:HGNC:5034]
Publication Statistics
PubMed Score 20.03
PubMed score by year
PubTator Score 23.80
PubTator score by year