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Tbio
HNRNPAB
Heterogeneous nuclear ribonucleoprotein A/B

Protein Summary
Description
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355836
  • ENSP00000348093
  • ENSG00000197451
  • ENST00000358344
  • ENSP00000351108
  • ENST00000504898
  • ENSP00000425031
  • ENST00000506259
  • ENSP00000427465

Symbol
  • ABBP1
  • HNRPAB
  • ABBP1
  • HNRPAB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
kinase perturbation
0.99
transcription factor perturbation
0.99
protein complex
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.65   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.65   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (192)
1 – 10 of 192
PTBP1
Tbio
Novelty: 0.00204645
Score: 0.943
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00503583
Score: 0.932
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01807307
Score: 0.929
Data Source: STRINGDB
UBE2G2
Tbio
Novelty: 0.05545031
Score: 0.888
Data Source: STRINGDB
HNRNPA3
Tbio
Novelty: 0.04579793
Score: 0.873
Data Source: STRINGDB
HNRNPD
Tbio
Novelty: 0.00623296
Score: 0.872
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.04447104
Score: 0.853
Data Source: STRINGDB
MRPS7
Tbio
Novelty: 0.00146168
Score: 0.843
Data Source: STRINGDB
ALYREF
Tbio
Novelty: 0.00114772
Score: 0.827
Data Source: STRINGDB
APOBEC1
Tbio
Novelty: 0.00924384
Score: 0.819
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.65

PubMed score by year
PubTator Score  23.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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