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Tbio
SLC30A3
Zinc transporter 3

Protein Summary
Description
Involved in accumulation of zinc in synaptic vesicles.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233535
  • ENSP00000233535
  • ENSG00000115194

Symbol
  • ZNT3
  • ZNT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
cellular component
0.8
small molecule perturbation
0.71
PubMedID
0.7
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.74   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.74   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
AP3D1
Tbio
Novelty:  0.04425592
Score:  0.817
Data Source:  STRINGDB
SLC30A9
Tbio
Family:  Transporter
Novelty:  0.07156604
Score:  0.799
Data Source:  STRINGDB
SLC39A7
Tbio
Family:  Transporter
Novelty:  0.01746862
Score:  0.759
Data Source:  STRINGDB
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
Score:  0.755
Data Source:  STRINGDB
SLC39A1
Tbio
Family:  Transporter
Novelty:  0.00678191
Score:  0.737
Data Source:  STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
Score:  0.737
Data Source:  STRINGDB
RTN3
Tbio
Novelty:  0.02373417
Score:  0.732
Data Source:  STRINGDB
SLC39A6
Tbio
Family:  Transporter
Novelty:  0.0144314
Score:  0.723
Data Source:  STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
Score:  0.721
Data Source:  STRINGDB
SLC39A14
Tbio
Family:  Transporter
Novelty:  0.01053215
Score:  0.719
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc efflux and compartmentalization by the SLC30 family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc efflux and compartmentalization by the SLC30 family
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
17
29
99.9
C-reactive protein measurement
2
7
7
98.2
total cholesterol measurement
2
5
4
3.9
96.1
urate measurement
1
4
4
95.6
apolipoprotein B measurement
1
5
5
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
29
99.9
C-reactive protein measurement
7
98.2
total cholesterol measurement
4
3.9
96.1
urate measurement
4
95.6
apolipoprotein B measurement
5
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 3
VGNC:7715
470339
Macaque
solute carrier family 30 member 3
699572
Mouse
MGI:1345280
22784
Rat
RGD:1359689
366568
Dog
solute carrier family 30 member 3
VGNC:46348
475700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 3
Macaque
solute carrier family 30 member 3
Mouse
Rat
Dog
solute carrier family 30 member 3
Publication Statistics
PubMed Score 168.74
PubMed score by year
PubTator Score 31.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title