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Tclin
SIGMAR1
Sigma non-opioid intracellular receptor 1

Protein Summary
Description
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277010
  • ENSP00000277010
  • ENSG00000147955
  • ENST00000353468
  • ENSP00000434453
  • ENST00000477726
  • ENSP00000420022

Symbol
  • OPRS1
  • SRBP
  • SRBP
  • ALS16
  • DSMA2
  • OPRS1
  • SR-BP
  • SIG-1R
  • SR-BP1
  • sigma1R
  • hSigmaR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
cellular component
0.86
transcription factor perturbation
0.8
disease perturbation
0.74
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 398.95   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 398.95   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2058
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 62
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (62)
chlorpromazine
Rendered image for chlorpromazine
amitriptyline
Rendered image for amitriptyline
thioridazine
Rendered image for thioridazine
clemastine
Rendered image for clemastine
fluphenazine
Rendered image for fluphenazine
haloperidol
Rendered image for haloperidol
prochlorperazine
Rendered image for prochlorperazine
quetiapine
Rendered image for quetiapine
ketanserin
Rendered image for ketanserin
clomipramine
Rendered image for clomipramine
Protein-Protein Interactions (103)
RTN1
Tbio
Novelty:  0.01828064
p_int:  0.987619744
p_ni:  0.012380256
Score:  0.246
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.969308644
p_ni:  0.030691356
Score:  0.177
Data Source:  BioPlex,STRINGDB
CYP51A1
Tchem
Family:  Enzyme
Novelty:  0.00127373
Score:  0.901
Data Source:  STRINGDB
ERG28
Tbio
Novelty:  0.04267481
Score:  0.901
Data Source:  STRINGDB
KCNH6
Tclin
Family:  IC
Novelty:  0.01126636
Score:  0.9
Data Source:  STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
Score:  0.898
Data Source:  STRINGDB
MSMO1
Tbio
Family:  Enzyme
Novelty:  0.01263528
Score:  0.893
Data Source:  STRINGDB
NSDHL
Tbio
Family:  Enzyme
Novelty:  0.01651408
Score:  0.891
Data Source:  STRINGDB
TM7SF2
Tbio
Family:  Enzyme
Novelty:  0.055054
Score:  0.802
Data Source:  STRINGDB
KCNA4
Tclin
Family:  IC
Novelty:  0.00362065
Score:  0.793
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
1
1
80.5
6
2
2
1.1
69.5
adolescent idiopathic scoliosis
2
1
0
1.1
42.3
testosterone measurement
1
1
1
29
self reported educational attainment
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
80.5
2
1.1
69.5
adolescent idiopathic scoliosis
0
1.1
42.3
testosterone measurement
1
29
self reported educational attainment
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sigma non-opioid intracellular receptor 1
VGNC:10120
465062
Macaque
sigma non-opioid intracellular receptor 1
700469
Mouse
MGI:1195268
18391
Rat
RGD:68364
29336
Dog
sigma non-opioid intracellular receptor 1
VGNC:46170
481587
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sigma non-opioid intracellular receptor 1
Macaque
sigma non-opioid intracellular receptor 1
Mouse
Rat
Dog
sigma non-opioid intracellular receptor 1
Publication Statistics
PubMed Score 398.95
PubMed score by year
PubTator Score 91.87
PubTator score by year
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Related Publications
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PMID
Year
Title