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Tbio
SEPT5
Septin-5

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby lar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000438754
  • ENSP00000394541
  • ENSG00000184702
  • ENST00000455784
  • ENSP00000391311

Symbol
  • PNUTL1
  • H5
  • CDCREL
  • PNUTL1
  • CDCREL1
  • CDCREL-1
  • HCDCREL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.93
molecular function
0.93
transcription factor perturbation
0.91
tissue sample
0.71
histone modification site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (93)
1 – 10 of 93
SEPT1
Tdark
Novelty: 0.00851061
p_int: 1
Score: 0.87
Data Source: BioPlex,STRINGDB
SEPT7
Tbio
Novelty: 0.00694959
p_int: 0.999999992
p_ni: 8e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
SEPT6
Tbio
Novelty: 0.00922092
p_int: 0.999999796
p_ni: 2.04e-7
Score: 0.965
Data Source: BioPlex,STRINGDB
SEPT12
Tbio
Novelty: 0.03406694
p_int: 0.999999312
p_ni: 6.88e-7
Score: 0.928
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.16043959
p_int: 0.999993187
p_ni: 0.000006813
Score: 0.361
Data Source: BioPlex,STRINGDB
SEPT3
Tbio
Novelty: 0.00937647
p_int: 0.999988071
p_ni: 0.00001191
p_wrong: 1.9e-8
Score: 0.938
Data Source: BioPlex,STRINGDB
SEPT2
Tbio
Novelty: 0.00437406
p_int: 0.999987613
p_ni: 0.000012387
Score: 0.905
Data Source: BioPlex,STRINGDB
CDC42EP4
Tdark
Novelty: 0.26677959
p_int: 0.999916103
p_ni: 0.000083896
p_wrong: 1e-9
Score: 0.9
Data Source: BioPlex,STRINGDB
ACAP3
Tdark
Novelty: 0.23762376
p_int: 0.999862652
p_ni: 0.000137348
Score: 0.338
Data Source: BioPlex,STRINGDB
SEPT10
Tbio
Novelty: 0.04560583
p_int: 0.999822204
p_ni: 0.000177795
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  56.12

PubMed score by year
PubTator Score  166.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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