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Tbio
SEPT5
Septin-5

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby lar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000438754
  • ENSP00000394541
  • ENSG00000184702
  • ENST00000455784
  • ENSP00000391311

Symbol
  • PNUTL1
  • H5
  • CDCREL
  • PNUTL1
  • CDCREL1
  • CDCREL-1
  • HCDCREL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.93
molecular function
0.93
transcription factor perturbation
0.91
tissue sample
0.71
histone modification site profile
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
septin 5
458652
Macaque
septin 5
712041
Mouse
MGI:1195461
18951
Rat
RGD:621763
116728
Dog
septin 5
VGNC:49944
486419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
septin 5
Macaque
septin 5
Mouse
Rat
Dog
septin 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q99719-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (93)
1 – 10 of 93
SEPT1
Tdark
Novelty: 0.04450119
p_int: 1
Score: 0.87
Data Source: BioPlex,STRINGDB
SEPT7
Tbio
Novelty: 0.00554708
p_int: 0.999999992
p_ni: 8e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
SEPT6
Tbio
Novelty: 0.00885503
p_int: 0.999999796
p_ni: 2.04e-7
Score: 0.965
Data Source: BioPlex,STRINGDB
SEPT12
Tbio
Novelty: 0.06228277
p_int: 0.999999312
p_ni: 6.88e-7
Score: 0.928
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.999993187
p_ni: 0.000006813
Score: 0.361
Data Source: BioPlex,STRINGDB
SEPT3
Tbio
Novelty: 0.008513
p_int: 0.999988071
p_ni: 0.00001191
p_wrong: 1.9e-8
Score: 0.938
Data Source: BioPlex,STRINGDB
SEPT2
Tbio
Novelty: 0.01047916
p_int: 0.999987613
p_ni: 0.000012387
Score: 0.905
Data Source: BioPlex,STRINGDB
CDC42EP4
Tdark
Novelty: 0.27965905
p_int: 0.999916103
p_ni: 0.000083896
p_wrong: 1e-9
Score: 0.9
Data Source: BioPlex,STRINGDB
ACAP3
Tbio
Novelty: 0.19558023
p_int: 0.999862652
p_ni: 0.000137348
Score: 0.338
Data Source: BioPlex,STRINGDB
SEPT10
Tbio
Novelty: 0.14834834
p_int: 0.999822204
p_ni: 0.000177795
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  59.16

PubMed score by year
PubTator Score  166.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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