SMAD5
Mothers against decapentaplegic homolog 5
Protein Summary
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
- ENST00000509297
- ENSP00000426696
- ENSG00000113658
- ENST00000545279
- ENSP00000441954
- ENST00000545620
- ENSP00000446474
- MADH5
- DWFC
- JV5-1
- MADH5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.97 | ||
molecular function | 0.93 | ||
transcription factor perturbation | 0.91 | ||
biological process | 0.9 | ||
microRNA | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 229.56 (req: < 5)
Gene RIFs: 66 (req: <= 3)
Antibodies: 519 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 229.56 (req: >= 5)
Gene RIFs: 66 (req: > 3)
Antibodies: 519 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0