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Tbio
SMAD5
Mothers against decapentaplegic homolog 5

Protein Summary
Description
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000509297
  • ENSP00000426696
  • ENSG00000113658
  • ENST00000545279
  • ENSP00000441954
  • ENST00000545620
  • ENSP00000446474

Symbol
  • MADH5
  • DWFC
  • JV5-1
  • MADH5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
molecular function
0.93
transcription factor perturbation
0.91
biological process
0.9
microRNA
0.9


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.46   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 519   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.46   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 519   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
SMURF2
Tchem
Family:  Enzyme
Novelty:  0.00920984
p_int:  0.999999913
p_ni:  5.8e-8
p_wrong:  3e-8
Score:  0.982
Data Source:  BioPlex,STRINGDB
SSMEM1
Tdark
Novelty:  1.77966102
p_int:  0.999980457
p_ni:  0.000019511
p_wrong:  3.2e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.999966372
p_ni:  0.000030457
p_wrong:  0.000003171
Data Source:  BioPlex
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
p_int:  0.99996282
p_ni:  0.000026625
p_wrong:  0.000010555
Data Source:  BioPlex
LSR
Tbio
Novelty:  0.00528058
p_int:  0.999390886
p_ni:  0.00060373
p_wrong:  0.000005384
Score:  0.189
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.948831279
p_ni:  0.000055852
p_wrong:  0.051112869
Data Source:  BioPlex
BMP2
Tbio
Novelty:  0.00016974
Score:  0.988
Data Source:  Reactome,STRINGDB
SMURF1
Tchem
Family:  Enzyme
Novelty:  0.00754708
Score:  0.987
Data Source:  STRINGDB
ACVR1
Tchem
Family:  Kinase
Novelty:  0.00284646
Score:  0.986
Data Source:  STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.984
Data Source:  Reactome,STRINGDB
Pathways (71)
Signal Transduction (R-HSA-162582)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
2
2
0
1.1
65.7
sleep duration
1
1
0
1
36.9
mean platelet volume
1
1
1
29
heel bone mineral density
3
1
3
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1.1
65.7
sleep duration
0
1
36.9
mean platelet volume
1
29
heel bone mineral density
3
27.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SMAD family member 5
712645
Mouse
MGI:1328787
17129
Rat
RGD:620158
59328
Dog
SMAD family member 5
VGNC:46522
481520
Horse
SMAD family member 5
VGNC:23314
100033851
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SMAD family member 5
Mouse
Rat
Dog
SMAD family member 5
Horse
SMAD family member 5
Publication Statistics
PubMed Score 208.46
PubMed score by year
PubTator Score 225.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title