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Tbio
COL12A1
Collagen alpha-1(XII) chain

Protein Classes
Protein Summary
Description
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322507
  • ENSP00000325146
  • ENSG00000111799
  • ENST00000345356
  • ENSP00000305147
  • ENST00000416123
  • ENSP00000412864

Symbol
  • COL12A1L
  • UCMD2
  • BTHLM2
  • EDSMYP
  • COL12A1L
  • BA209D8.1
  • DJ234P15.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
protein domain
0.85
PubMedID
0.84
transcription factor binding site profile
0.77
gene perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.45   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.45   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
1
0
2.2
62.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.2
62.7
Pathways (10)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Protein-Protein Interactions (113)
1 – 10 of 113
LAIR2
Tbio
Novelty: 0.06117644
p_int: 0.99999999
p_ni: 9e-9
p_wrong: 1e-9
Data Source: BioPlex
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
p_int: 0.999999898
p_ni: 9.5e-8
p_wrong: 7e-9
Score: 0.473
Data Source: BioPlex,STRINGDB
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
p_int: 0.999976774
p_ni: 4.9e-7
p_wrong: 0.000022737
Score: 0.55
Data Source: BioPlex,STRINGDB
COL5A2
Tbio
Novelty: 0.01352973
Score: 0.968
Data Source: STRINGDB
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.963
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.96
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.955
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.952
Data Source: STRINGDB
SERPINH1
Tbio
Novelty: 0.00106715
Score: 0.95
Data Source: STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.45

PubMed score by year
PubTator Score  23.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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