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Tchem
HSD17B10
3-hydroxyacyl-CoA dehydrogenase type-2

Protein Summary
Description
Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecule ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000168216
  • ENSP00000168216
  • ENSG00000072506
  • ENST00000375304
  • ENSP00000364453

Symbol
  • ERAB
  • HADH2
  • MRPP2
  • SCHAD
  • SDR5C1
  • XH98G2
  • ABAD
  • CAMR
  • ERAB
  • HCD2
  • MHBD
  • HADH2
  • MRPP2
  • MRX17
  • MRX31
  • SCHAD
  • MRXS10
  • SDR5C1
  • HSD10MD
  • 17b-HSD10
  • DUPXp11.22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.96
kinase perturbation
0.96
virus perturbation
0.92
transcription factor perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.68   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 499   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.68   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 499   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 10
VGNC:12408
465649
Macaque
hydroxysteroid 17-beta dehydrogenase 10
700018
Mouse
MGI:1333871
15108
Rat
RGD:69231
63864
Dog
hydroxysteroid 17-beta dehydrogenase 10
VGNC:41801
480930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 17-beta dehydrogenase 10
Macaque
hydroxysteroid 17-beta dehydrogenase 10
Mouse
Rat
Dog
hydroxysteroid 17-beta dehydrogenase 10
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99714-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Metabolism of amino acids and derivatives
Reactome
rRNA processing
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of RNA
Metabolism of amino acids and derivatives
rRNA processing
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (160)
1 – 10 of 160
IGHG2
Tdark
p_int: 0.823348607
p_ni: 0.176574343
p_wrong: 0.000077049
Data Source: BioPlex
TRMT10C
Tbio
Family: Enzyme
Novelty: 0.07045719
p_int: 0.811403461
p_ni: 0.188596539
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
IGHG1
Tdark
p_int: 0.760449348
p_ni: 0.239550652
Data Source: BioPlex
ECHS1
Tbio
Family: Enzyme
Novelty: 0.01291476
Score: 0.992
Data Source: STRINGDB
HADHB
Tbio
Family: Enzyme
Novelty: 0.00969194
Score: 0.99
Data Source: STRINGDB
KIAA0391
Tbio
Family: Enzyme
Novelty: 0.02276396
Score: 0.987
Data Source: Reactome,STRINGDB
ACAA2
Tbio
Family: Enzyme
Novelty: 0.01452373
Score: 0.972
Data Source: STRINGDB
ACAA1
Tbio
Family: Enzyme
Novelty: 0.00710465
Score: 0.944
Data Source: STRINGDB
HADH
Tbio
Family: Enzyme
Novelty: 0.00368073
Score: 0.942
Data Source: STRINGDB
HADHA
Tbio
Novelty: 0.00385746
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  194.68

PubMed score by year
PubTator Score  162.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer