Tbio KCNJ15 ATP-sensitive inward rectifier potassium channel 15

Protein Summary

Description

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

Uniprot Accession IDs

• Q99712
• D3DSH5
• O00564
• Q96L28
• Q99446

Gene Name

• KCNJ15

Ensembl ID

• ENST00000328656
• ENSP00000331698
• ENSG00000157551
• ENST00000398930
• ENSP00000381904
• ENST00000398932
• ENSP00000381905
• ENST00000398934
• ENSP00000381907
• ENST00000398938
• ENSP00000381911
• ENST00000612702
• ENSP00000484960
• ENST00000613499
• ENSP00000479100

Symbol

• KCNJ14
• IRKK
• KIR1.3
• KIR4.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
gene perturbation	0.8
transcription factor	0.66
cell type or tissue	0.65
cell line	0.62

Protein Classes

DTO Classes

Protein / Ion Channel / Inward Rectifier-type Potassium Channel Family / Kcnj15 Subfamily / Atp-sensitive Inward Rectifier Potassium Channel 15

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.62   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.62   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0