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Tbio
RBBP8
DNA endonuclease RBBP8

Protein Summary
Description
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:10764811, PubMed:10910365, PubMed:15485915, PubMed:16581787, PubMed:16818604, PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:20829486). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327155
  • ENSP00000323050
  • ENSG00000101773
  • ENST00000399722
  • ENSP00000382628
  • ENST00000399725
  • ENSP00000382630

Symbol
  • CTIP
  • RIM
  • COM1
  • CTIP
  • JWDS
  • SAE2
  • SCKL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
virus perturbation
0.96
molecular function
0.9
transcription factor perturbation
0.88
biological process
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.42   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 407   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.42   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
9
11
89
eosinophil percentage of leukocytes
2
2
2
73
BMI-adjusted hip circumference
2
4
5
68.5
eosinophil count
2
2
2
65.6
lymphocyte count
2
1
2
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
11
89
eosinophil percentage of leukocytes
2
73
BMI-adjusted hip circumference
5
68.5
eosinophil count
2
65.6
lymphocyte count
2
65.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 8, endonuclease
VGNC:5200
455333
Mouse
MGI:2442995
225182
Rat
RGD:1308872
291787
Dog
RB binding protein 8, endonuclease
VGNC:45394
480175
Horse
RB binding protein 8, endonuclease
VGNC:22222
100050857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 8, endonuclease
Mouse
Rat
Dog
RB binding protein 8, endonuclease
Horse
RB binding protein 8, endonuclease
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99708-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
G2/M Checkpoints
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (229)
1 – 10 of 229
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999935741
p_ni:  0.000064249
p_wrong:  1e-8
Data Source:  BioPlex
SCOC
Tbio
Novelty:  0.05277646
p_int:  0.998817616
p_ni:  0.001177889
p_wrong:  0.000004496
Score:  0.219
Data Source:  BioPlex,STRINGDB
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.961828884
p_ni:  0.000555248
p_wrong:  0.037615868
Score:  0.239
Data Source:  BioPlex,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.997
Data Source:  Reactome,STRINGDB
BARD1
Tbio
Novelty:  0.00513841
Score:  0.996
Data Source:  Reactome,STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.995
Data Source:  Reactome,STRINGDB
EXO1
Tbio
Family:  Enzyme
Novelty:  0.00130104
Score:  0.993
Data Source:  Reactome,STRINGDB
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
Score:  0.992
Data Source:  Reactome,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
Score:  0.99
Data Source:  Reactome,STRINGDB
CTBP1
Tbio
Novelty:  0.00243818
Score:  0.982
Data Source:  STRINGDB
Publication Statistics
PubMed Score  247.42

PubMed score by year
PubTator Score  114.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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