Protein Summary
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). This gene encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
- ENST00000366577
- ENSP00000355536
- ENSG00000116984
- ENST00000535889
- ENSP00000441845
- MS
- HMAG
- cblG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
virus perturbation | 0.92 | ||
biological term | 0.81 | ||
molecular function | 0.79 | ||
disease | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1388.19 (req: < 5)
Gene RIFs: 186 (req: <= 3)
Antibodies: 138 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1388.19 (req: >= 5)
Gene RIFs: 186 (req: > 3)
Antibodies: 138 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
AKAP13
Family: Enzyme
Novelty: 0.00726267
p_int: 0.973033889
p_ni: 0.026966111
Score: 0.547
Data Source: BioPlex,STRINGDB
LINC01587
Novelty: 0.48128342
p_int: 0.82455828
p_ni: 0.17544172
Score: 0.169
Data Source: BioPlex,STRINGDB
LPCAT1
Family: Enzyme
Novelty: 0.01441133
p_int: 0.77719851
p_ni: 0.22280149
Score: 0.332
Data Source: BioPlex,STRINGDB
SPATA5L1
Family: Enzyme
Novelty: 0.5393372
p_int: 0.75330537
p_ni: 0.24669463
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (5)
Upstream (2)
Downstream (3)
Pathways (40)
Reactome (15)
KEGG (5)
PathwayCommons (5)
UniProt (1)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defective MTR causes methylmalonic aciduria and homocystinuria type cblG | ||||
Reactome | Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE | ||||
Reactome | Defects in cobalamin (B12) metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG | ||||
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE | ||||
Defects in cobalamin (B12) metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (1)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CACAO | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 1 | 2 | 61 | |||||
homocysteine measurement | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 61 | |||||
homocysteine measurement | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | 5-methyltetrahydrofolate-homocysteine methyltransferase | VGNC:1338 | 457844 | |||||
Macaque | 5-methyltetrahydrofolate-homocysteine methyltransferase | 717582 | ||||||
Mouse | MGI:894292 | 238505 | ||||||
Rat | RGD:621283 | 81522 | ||||||
Dog | 5-methyltetrahydrofolate-homocysteine methyltransferase | VGNC:43491 | 479190 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | 5-methyltetrahydrofolate-homocysteine methyltransferase | |||||
Macaque | 5-methyltetrahydrofolate-homocysteine methyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | 5-methyltetrahydrofolate-homocysteine methyltransferase | |||||
Publication Statistics
PubMed Score 1388.19
PubMed score by year
PubTator Score 382.59
PubTator score by year
Related Publications
Text Mined References (382)
GeneRif Annotations (186)
Items per page:
0 of 0
PMID | Year | Title |
|---|