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Tbio
KIR2DL4
Killer cell immunoglobulin-like receptor 2DL4

Protein Summary
Description
Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response (PubMed:20179272). Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by nat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345540
  • ENSP00000339634
  • ENSG00000189013
  • ENST00000357494
  • ENSP00000350088
  • ENST00000396293
  • ENSP00000379588
  • ENST00000611022
  • ENSP00000484469
  • ENSG00000274232
  • ENST00000612573
  • ENSP00000482206
  • ENSG00000275456
  • ENST00000612660
  • ENSP00000479179
  • ENSG00000275317
  • ENST00000613053
  • ENSP00000484389
  • ENSG00000277362
  • ENST00000614653
  • ENSP00000478362
  • ENSG00000277750
  • ENST00000614680
  • ENSP00000477984
  • ENSG00000273575
  • ENST00000615232
  • ENSP00000479874
  • ENST00000615243
  • ENSP00000482454
  • ENST00000615970
  • ENSP00000477887
  • ENSG00000278271
  • ENST00000616354
  • ENSP00000483782
  • ENSG00000278430
  • ENST00000616384
  • ENSP00000479347
  • ENSG00000276044
  • ENST00000618297
  • ENSP00000477886
  • ENSG00000278074
  • ENST00000618358
  • ENSP00000483101
  • ENSG00000274609
  • ENST00000618567
  • ENSP00000482383
  • ENSG00000276779
  • ENST00000619637
  • ENSP00000478491
  • ENSG00000274955
  • ENST00000619848
  • ENSP00000480801
  • ENSG00000277964
  • ENST00000620484
  • ENSP00000477601
  • ENST00000620486
  • ENSP00000482452
  • ENST00000621182
  • ENSP00000479175
  • ENSG00000275699
  • ENST00000638231
  • ENSP00000492368
  • ENSG00000284460
  • ENST00000638248
  • ENSP00000491734
  • ENSG00000284365
  • ENST00000638297
  • ENSP00000492029
  • ENST00000638563
  • ENSP00000491532
  • ENSG00000284013
  • ENST00000638897
  • ENSP00000492653
  • ENSG00000283961
  • ENST00000639460
  • ENSP00000491648
  • ENSG00000283869
  • ENST00000639533
  • ENSP00000491289
  • ENST00000639577
  • ENSP00000492722
  • ENST00000639740
  • ENSP00000492606
  • ENSG00000284509
  • ENST00000639866
  • ENSP00000491202
  • ENST00000640163
  • ENSP00000491890
  • ENST00000640814
  • ENSP00000491623

Symbol
  • CD158D
  • KIR103AS
  • G9P
  • CD158D
  • KIR103
  • KIR-2DL4
  • KIR103AS
  • KIR-103AS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.99
cell type or tissue
0.93
microRNA
0.68
biological term
0.65
cell line
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 697.66   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 697.66   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0