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Tchem
MCHR1
Melanin-concentrating hormone receptor 1

Protein Summary
Description
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249016
  • ENSP00000249016
  • ENSG00000128285

Symbol
  • GPR24
  • SLC1
  • SLC1
  • GPR24
  • MCH1R
  • SLC-1
  • MCH-1R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.89
hub protein
0.82
cell type or tissue
0.61
cellular component
0.61
molecular function
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.14   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.14   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2014
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (14)
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Cilium Assembly
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (404)
1 – 10 of 404
PMCH
Tbio
Novelty: 0.005002
Score: 0.981
Data Source: Reactome,STRINGDB
BBS4
Tbio
Novelty: 0.02877292
Score: 0.96
Data Source: STRINGDB
BBS2
Tbio
Novelty: 0.00218065
Score: 0.958
Data Source: STRINGDB
HCRT
Tbio
Novelty: 0.00044523
Score: 0.958
Data Source: STRINGDB
HTR5A
Tchem
Family: GPCR
Novelty: 0.01826019
Score: 0.955
Data Source: STRINGDB
BBS1
Tbio
Novelty: 0.01526746
Score: 0.954
Data Source: STRINGDB
EDN2
Tbio
Novelty: 0.00287223
Score: 0.953
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00014761
Score: 0.951
Data Source: STRINGDB
BBS7
Tbio
Novelty: 0.06755563
Score: 0.951
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00230753
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  315.14

PubMed score by year
PubTator Score  183.32

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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