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Tbio
DOK1
Docking protein 1

Protein Summary
Description
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233668
  • ENSP00000233668
  • ENSG00000115325
  • ENST00000340004
  • ENSP00000344330
  • ENST00000409429
  • ENSP00000387016

Symbol
  • pp62
  • P62DOK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
hub protein
0.9
kinase
0.84
co-expressed gene
0.82
histone modification site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.86   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 819   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.86   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 819   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
38.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
38.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
docking protein 1
VGNC:2929
741064
Macaque
docking protein 1
710118
Mouse
MGI:893587
13448
Rat
RGD:1309499
312477
Dog
docking protein 1
VGNC:40055
483100
Species
Name
OMA
EggNOG
Inparanoid
Chimp
docking protein 1
Macaque
docking protein 1
Mouse
Rat
Dog
docking protein 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q99704-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (339)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Reactome
RET signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RET signaling
Signal Transduction
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (87)
1 – 10 of 87
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
p_int: 0.99806142
p_ni: 6.1e-8
p_wrong: 0.001938519
Score: 0.187
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.929111623
p_ni: 6e-9
p_wrong: 0.070888371
Score: 0.718
Data Source: BioPlex,STRINGDB
RASA1
Tbio
Family: Enzyme
Novelty: 0.00425286
Score: 0.979
Data Source: STRINGDB
CSK
Tchem
Family: Kinase
Novelty: 0.00186612
Score: 0.975
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.974
Data Source: STRINGDB
NCK1
Tbio
Novelty: 0.00352084
Score: 0.972
Data Source: STRINGDB
RET
Tclin
Family: Kinase
Novelty: 0.00028324
Score: 0.972
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.971
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.968
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.86

PubMed score by year
PubTator Score  55.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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