Tbio PITX2 Pituitary homeobox 2

Protein Summary

Description

Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity). This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99697
• A8K6C6
• B2RA02
• B3KXS0
• O60578
• O60579
• O60580
• Q3KQX9
• Q9BY17

Gene Name

• PITX2

Ensembl ID

• ENST00000306732
• ENSP00000304169
• ENSG00000164093
• ENST00000354925
• ENSP00000347004
• ENST00000355080
• ENSP00000347192
• ENST00000394595
• ENSP00000378095
• ENST00000394598
• ENSP00000378097
• ENST00000613094
• ENSP00000484763
• ENST00000614423
• ENSP00000481951
• ENST00000616641
• ENSP00000484909
• ENST00000644743
• ENSP00000495061

Symbol

• ARP1
• RGS
• RIEG
• RIEG1
• RS
• RGS
• ARP1
• Brx1
• IDG2
• IGDS
• IHG2
• PTX2
• RIEG
• ASGD4
• IGDS2
• IRID2
• Otlx2
• RIEG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
molecular function	0.99
hub protein	0.98
PubMedID	0.88
transcription factor	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 603.41   (req: < 5)

Gene RIFs: 168   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 603.41   (req: >= 5)

Gene RIFs: 168   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0