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Tchem
MGLL
Monoglyceride lipase

Protein Summary
Description
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333). This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398104
  • ENSP00000381176
  • ENSG00000074416
  • ENST00000434178
  • ENSP00000402798
  • ENST00000453507
  • ENSP00000404146

Symbol
  • MGL
  • HUK5
  • MAGL
  • HU-K5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
PubMedID
0.99
gene perturbation
0.97
transcription factor perturbation
0.96
virus perturbation
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 571.83   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 413   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 571.83   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 169
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
thiram
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
1
1
0
1.1
31.8
platelet count
1
1
1
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
31.8
platelet count
1
13.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
monoglyceride lipase
VGNC:2047
739167
Macaque
monoglyceride lipase
100429242
Mouse
MGI:1346042
23945
Rat
RGD:71039
29254
Dog
monoglyceride lipase
VGNC:54327
476511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
monoglyceride lipase
Macaque
monoglyceride lipase
Mouse
Rat
Dog
monoglyceride lipase
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (70)
Acyl chain remodeling of DAG and TAG (R-HSA-1482883)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of DAG and TAG
Reactome
Arachidonate production from DAG
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of DAG and TAG
Arachidonate production from DAG
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Protein-Protein Interactions (166)
1 – 10 of 166
SPATA46
Tdark
Novelty: 0.327066
p_int: 0.999239975
p_ni: 0.000752525
p_wrong: 0.0000075
Score: 0.29
Data Source: BioPlex,STRINGDB
USE1
Tbio
Novelty: 0.00904756
p_int: 0.99521191
p_ni: 0.000656108
p_wrong: 0.004131983
Score: 0.228
Data Source: BioPlex,STRINGDB
HPCAL1
Tbio
Novelty: 0.04434155
p_int: 0.994023609
p_ni: 0.005884595
p_wrong: 0.000091797
Score: 0.312
Data Source: BioPlex,STRINGDB
PNPLA2
Tchem
Family: Enzyme
Novelty: 0.00149181
Score: 0.975
Data Source: STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.955
Data Source: STRINGDB
MOGAT2
Tchem
Family: Enzyme
Novelty: 0.06314447
Score: 0.95
Data Source: STRINGDB
LIPC
Tchem
Family: Enzyme
Novelty: 0.00219107
Score: 0.945
Data Source: STRINGDB
MOGAT1
Tbio
Family: Enzyme
Novelty: 0.0503068
Score: 0.941
Data Source: STRINGDB
PNLIP
Tclin
Family: Enzyme
Novelty: 0.00043254
Score: 0.94
Data Source: STRINGDB
FAAH
Tchem
Family: Enzyme
Novelty: 0.00162361
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  571.83

PubMed score by year
PubTator Score  218.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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