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Tbio
GFI1
Zinc finger protein Gfi-1

Protein Summary
Description
Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB prom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294702
  • ENSP00000294702
  • ENSG00000162676
  • ENST00000370332
  • ENSP00000359357
  • ENST00000427103
  • ENSP00000399719

Symbol
  • ZNF163
  • SCN2
  • GFI-1
  • GFI1A
  • ZNF163
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
gene perturbation
0.91
molecular function
0.73
transcription factor
0.73
phenotype
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.26   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.26   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (132)
1 – 10 of 132
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.944
Data Source:  STRINGDB
ZBTB17
Tbio
Family:  TF
Novelty:  0.0503245
Score:  0.94
Data Source:  STRINGDB
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.92
Data Source:  STRINGDB
DNMT3A
Tclin
Family:  Epigenetic
Novelty:  0.00085974
Score:  0.916
Data Source:  STRINGDB
MAX
Tbio
Family:  TF
Novelty:  0.00799068
Score:  0.903
Data Source:  STRINGDB
POU4F3
Tbio
Family:  TF
Novelty:  0.01131683
Score:  0.801
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.785
Data Source:  STRINGDB
ID2
Tbio
Family:  TF
Novelty:  0.00256364
Score:  0.761
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.748
Data Source:  STRINGDB
CEBPE
Tbio
Family:  TF
Novelty:  0.01183291
Score:  0.715
Data Source:  STRINGDB
Pathways (26)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of granulopoiesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of granulopoiesis
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
5
6
98.9
3
3
0
1.2
91.6
monocyte count
1
1
1
83.3
low density lipoprotein cholesterol measurement
4
4
9
78.5
total cholesterol measurement
4
4
8
78
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
6
98.9
0
1.2
91.6
monocyte count
1
83.3
low density lipoprotein cholesterol measurement
9
78.5
total cholesterol measurement
8
78
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
growth factor independent 1 transcriptional repressor
706481
Mouse
MGI:103170
14581
Rat
RGD:2680
24388
Dog
growth factor independent 1 transcriptional repressor
VGNC:41181
490156
Horse
growth factor independent 1 transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4237]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
growth factor independent 1 transcriptional repressor
Mouse
Rat
Dog
growth factor independent 1 transcriptional repressor
Horse
growth factor independent 1 transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4237]
Publication Statistics
PubMed Score 247.26
PubMed score by year
PubTator Score 167.93
PubTator score by year